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Bone Turnover Biochemical MarkerAka: Bone Remodeling Chemical Marker

See Also
1. Bone Densitometry
2. Bone Physiology
Indications (used more as a research tool currently)
1. Monitor peri-menopausal and postmenopausal bone loss
2. Monitor treatment outcomes
Bone formation (Serum markers)
1. Alkaline Phosphatase (total)
2. Alkaline Phosphatase (skeletal isoenzymes)
3. Procollagen-I Extension peptide
4. Osteocalcin
Bone resorption (Urine markers)
1. Urine Calcium
2. Urine hydroxyproline
3. Collagen cross-link fragments (first to be hydrolyzed)
  1. Urine Total pyridinoline
  2. Urine Free deoxypyridinoline
  3. Urine N-Telopeptide (n-terminus of collagen fibril)
  4. Urine C-Telopeptide (c-terminus of collagen fibril)
References
1. Rosen (1998) Postgrad Med 104(4):101

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.