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Anti-Topoisomerase I AntibodyAka: Anti-Scl-70 Antibody, Anti-Topoisomerase I, Anti-DNA-Topoisomerase I, Anti-Scl-70

See Also
1. Antinuclear Antibody
Negative
1. Normal
Positive (Percentage refers to sensitivity)
1. Scleroderma (20-30% sensitivity)
  1. Anti-Scl-70 is highly specific for Scleroderma
  2. Implies a poor prognosis
2. Associated with renal involvement
References
1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
3. Callegari (1995) Postgrad Med 97(4):65
4. Lane (2002) Am Fam Physician 65(6):1073

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