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Anti-Double Stranded DNA AntibodyAka: Anti-dsDNA Antibody, Double Stranded DNA Antibody, Anti-dsDNA

See Also
1. Antinuclear Antibody
Indication
1. Highly specific for Systemic Lupus Erythematosus
Normal
1. Negative
Positive (percentage refers to sensitivity)
1. Systemic Lupus Erythematosus (60%)
  1. Associated with Lupus Nephritis
  2. Associated with Lupus CNS Involvement
  3. Correlates with disease activity
2. Sjogren's Syndrome (5%)
3. Rheumatoid Arthritis (<5%)
4. Chronic active hepatitis
5. Biliary Cirrhosis
6. Epstein Barr Virus
7. Cytomegalovirus
References
1. Gladman in Klippel (1997) Rheumatic Diseases p. 255-6
2. Peng in Ruddy (2001) Kelley's Rheumatology, p. 161-72
3. Callegari (1995) Postgrad Med 97(4):65
4. Lane (2002) Am Fam Physician 65(6):1073

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