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Amyloidosis

Pathophysiology
1. Disturbed endogenous protein metabolism
  1. Primary
  2. Secondary to chronic tissue breakdown
2. Organ dysfunction arises from deposition
Symptoms
1. Asthenia
2. Weight loss
3. Paresthesias
4. Organ specific symptoms
Signs
1. Organ specific signs
2. Macroglossia
3. Hypertension
4. Lymphadenopathy
5. Hepatomegaly
6. Splenomegaly
7. Purpura
8. Nephrotic Syndrome
9. Edema
10. Joint pain, muscle pain
11. Serous cavity fluid
Labs
1. Biopsy under Congo red or thioflavine-T staining
  1. Exam of Gingiva, rectum, involved tissues
  2. Green birefringence in polarized light
2. Serum Immunoglobulins altered

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