II. Background

  1. Protein (120 amino acid) found in all human cells with a nucleus, as well as nearly all body fluids and tissues

III. Indications

  1. Alternative to Serum Creatinine as a measure of GFR
    1. Consider when estimated GFR is decreased, with suspected false positive test
    2. Abnormal GFR measurement with no known structural Kidney disease, CKD risk factors or albuminuria

IV. Contraindications (inaccurate Serum Cystatin-C)

  1. Acute Kidney Injury
  2. Inflammatory states
  3. Thyroid dysfunction

V. Disadvantages

  1. May not be available at all facilities

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