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Poststreptococcal GlomerulonephritisAka: Post-Streptococcal Glomerulonephritis

See Also
1. Acute Glomerulonephritis
Epidemiology
1. Most common cause of Glomerulonephritis
2. Most often in childhood (ages 2 to 6)
Pathophysiology
1. Prototype for Acute Glomerulonephritis
2. Follows Group A Beta Hemolytic Streptococcus Infection
3. Onset 10-14 days after infection
  1. Streptococcal Pharyngitis
  2. Scarlet Fever
Symptoms: Nephritic Syndrome
1. Oliguric Acute Renal Failure
2. Gross Hematuria
3. Flank pain is variably present
4. General symptoms
  1. Headache
  2. Anorexia
  3. Nausea or Vomiting
Signs
1. Hypertension
2. Edema
Labs
1. Throat Culture
2. Skin Culture
3. ASO Titer increased on serial measurements
4. Serum Complement decreased
Diagnosis: Renal biopsy
1. Indications: Diffuse proliferative Glomerulonephritis
  1. Severe or progressive Renal Failure
  2. Delayed resolution of clinical illness
  3. Systemic signs (joint pain, fever, Hepatomegaly)
Prognosis
1. Most cases are self limited (95%)
  1. Resolve within 4 weeks without residua
2. Adults do worse then children
  1. Higher risk of Chronic Glomerulonephritis

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.