http://www.fpnotebook.com/

Nephrotic SyndromeAka: Nephrosis

Epidemiology
1. Uncommon
Etiology
1. Primary glomerulonephropathy progresses to Nephrosis
  1. Occurs in 20% of cases
2. Children
  1. Minimal Change Disease (NIL Lesion)
3. Adults
  1. Membranous Nephropathy (50%)
  2. Minimal Change Disease (25%)
  3. Focal Glomerulosclerosis (15%)
  4. Other
    1. Systemic Lupus Erythematosus
    2. Membranoproliferative Glomerulonephritis (MPGN)
    3. IgA Nephropathy
    4. Diabetic glomerulosclerosis
    5. Amyloidosis
    6. Goodpasture's Syndrome
    7. Hodgkin's Lymphoma
    8. Preeclampsia or Eclampsia
    9. Drugs
      1. Penicillamine
      2. Gold
    10. Infection (includes PSGN)
Signs and Symptoms
1. Edema
2. Hypoalbuminemia
3. Hyperalbuminuria (Proteinuria >3.5 grams per day)
4. Hypertension
5. Hyperlipidemia
6. Renal Insufficiency
Management
1. Symptomatic
  1. Protein restriction
  2. Fluid restriction
  3. Diuretics
    1. Thiazide Diuretic
    2. Loop Diuretic
2. Prednisone
3. Cytotoxic agents

Navigation Tree

Please see the Terms and Conditions. Please also see the privacy statement regarding advertising on this page. Although access to this page is not restricted, the information found here is intended for use by medical providers. Patients should address specific medical concerns with their physicians.

This page was written by Scott Moses, MD, and was last revised 1/27/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 5.0.