Mental Health Book

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Nonbenzodiazepine Sedative-Hypnotic

Aka: Nonbenzodiazepine Sedative-Hypnotic, Nonbenzodiazepine hypnotic agent
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  1. See Also
    1. Insomnia
  2. Preparations
    1. Zolpidem (Ambien) or Zolpidem CR
    2. Zaleplon (Sonata)
    3. Eszopiclone (Lunesta)
  3. Adverse Effects
    1. Headache
    2. Dizziness
    3. Nausea
  4. Pharmacokinetics
    1. All are metabolized by CYP450 3A4
  5. Drug Interactions
    1. Alcohol and other CNS depressants have additive effect
    2. Narcotic concurrent use may cause excess Sedation
  6. Advantages
    1. Less Anticholinergic affect than other hypnotics
    2. Low addictive potential compared with Benzodiazepines
    3. Minimal effect on Sleep Stages
    4. Lack of withdrawal side effects
    5. No rebound Insomnia
    6. Little or no tolerance, effective to 1 year
  7. Disadvantages
    1. Expensive (>$100 per month for all agents in class)

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