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Nonbenzodiazepine Sedative-HypnoticAka: Nonbenzodiazepine hypnotic agent

See Also
1. Insomnia
Preparations
1. Zolpidem (Ambien) or Zolpidem CR
2. Zaleplon (Sonata)
3. Eszopiclone (Lunesta)
Adverse Effects
Pharmacokinetics
1. All are metabolized by CYP450 3A4
Drug Interactions
1. Alcohol and other CNS depressants have additive effect
2. Narcotic concurrent use may cause excess Sedation
Advantages
1. Less anticholinergic affect than other hypnotics
2. Low addictive potential compared with Benzodiazepines
3. Minimal effect on Sleep Stages
4. Lack of withdrawal side effects
5. No rebound Insomnia
6. Little or no tolerance, effective to 1 year
Disadvantages
1. Expensive (>$100 per month for all agents in class)

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 6/1/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.

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Nonbenzodiazepine Sedative-HypnoticAka: Nonbenzodiazepine hypnotic agent

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