Mental Health Book

Chemical Dependency

Miscellaneous

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SerotoninAka: Serotoninergic, 5-Hydroxytryptamine, 5-HT

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  1. See Also
    1. Serotonin Syndrome
    2. Carcinoid Syndrome
  2. Physiology
    1. Neurotransmitter
      1. Motor control
      2. Pain perception
      3. Sympathetic nervous system outflow
    2. Synthesis from essential amino acid L-tryptophan
    3. Serotonin Receptors
      1. Serotonin-1 Receptor (5-HT-1) Activity
        1. Anti-depressant effect
      2. Serotonin-2 Receptor (5-HT-2) Activity
        1. Inhibits 5-HT-1 Receptor
        2. Causes sexual dysfunction
        3. Causes Insomnia
        4. Causes anxiety
      3. Serotonin-3 Receptor (5-HT-3) Activity
        1. Causes Gastrointestinal symptoms
        2. Causes Headache
  3. Medications that increase serotonin levels
    1. Increased serotonin synthesis: L-Tryptophan
    2. Decrease serotonin metabolism: MAO inhibitors
    3. Increase serotonin release: Amphetamines, Cocaine
    4. Inhibit serotonin uptake
      1. Tricyclic Antidepressants: Amitriptyline
      2. Selective Serotonin Reuptake Inhibitor (SSRI): Prozac
      3. Other: Meperidine, Dextromethorphan
    5. Direct Serotonin Receptor Agonists: Buspar, Imitrex
    6. Dopamine agonists: Amantadine, Wellbutrin, Levodopa
    7. Other Non-specific Serotonin increase: Lithium

Serotonin (C0036751)

Definition (MSH)A biochemical messenger and regulator, synthesized from the essential amino acid L-TRYPTOPHAN. In humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets. Serotonin mediates several important physiological functions including neurotransmission, gastrointestinal motility, hemostasis, and cardiovascular integrity. Multiple receptor families (RECEPTORS, SEROTONIN) explain the broad physiological actions and distribution of this biochemical mediator.
Definition (CSP)biochemical messenger and regulator, synthesized from tryptophan; in humans it is found primarily in the central nervous system, gastrointestinal tract, and blood platelets.
ConceptsOrganic Chemical (T109) , Neuroreactive Substance or Biogenic Amine (T124)
MSHD012701
English5 hydroxytryptamine, 5-HT, 5-HT - 5-Hydroxytryptamine, 5-Hydroxy tryptamine, 5-Hydroxytryptamine, 5HT, Enteramine, Hippophaine, HT 05, HYDROXYTRYPTAMINE A 05, Serotonin
Spanish5 - hidroxi triptamina, 5 - hidroxitriptamina, serotonina
Parent Conceptstryptamine (C0077431), Neurotransmitters (C0027908), Autacoids (C0037343), Tryptamines (C0041248), indolamine (C0083001), Mediator of immune response (C0301974), Peptide hormones and their metabolites and precursors (C0582246)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, NCI, SCTSPA, SNOMEDCT, UWDA
Derived from the NIH UMLS (Unified Medical Language System)



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