Rohypnol

Aka: Rohypnol, Flunitrazepam

1. Street Names
   1. Roachies
   2. La Rocha
   3. Rope
   4. Rib Roche
   5. Roofies
   6. Ruffies
   7. Mexican Valium
   8. Rophies
   9. Forget-me pill
2. Illicit Uses
   1. Date Rape Drug
   2. Calm down after Cocaine
3. Medical Uses
   1. Sedative-Hypnotic for Insomnia (Sleep aid)
   2. Pre-surgical sedative
4. Pharmacokinetics
   1. Benzodiazepine (similar to Versed)
      1. Relative potency to Valium: 10 fold more potent
   2. Typical Dosages: 1-2 mg
   3. Onset effect 20-30 minutes
   4. Peak effect 1-2 hours
   5. Sedative Effect after 2 mg tab: 6-8 hours
      1. Duration longer when combined with Alcohol or drugs
   6. Dissolves in frothy drinks (Daiquiri, Margarita)
5. Effects
   1. Lower dose (1-2 mg)
      1. Relaxes skeletal muscle and impairs motor skills
      2. Reduces inhibitions and impairs judgment
      3. Reduces anxiety
   2. Higher dose
      1. Appears Drunk
      2. Dizziness
      3. Confusion
      4. Amnestic effect (variable, may be over 24 hours)
      5. Loss or Altered Level of Consciousness
6. Toxicology: Gas chromatography Urine Sample
   1. Metabolites detected up to 72 hours after 2 mg tablet
      1. Main metabolite: 7-amino-Flunitrazepam
   2. Needs to be sent to special lab
   3. Hoffmann-La Roche offers free testing
      1. General Info: 800-720-1076
      2. Testing: 800-608-6540
   4. Also detects
      1. Other Benzodiazepines
      2. Marijuana
      3. Cocaine
      4. Some opiates
      5. Some Barbiturates
7. Drug Interactions (may be lethal in combination)
   1. Alcohol
   2. Narcotics
   3. CNS depressants
8. Antidote
   1. Flumazenil
9. References
   1. Schwartz (1997) Acad Emerg Med 4:323-6