Prevention Book

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Family HistoryAka: Pedigree

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  1. Percentage of shared genes among relatives
    1. First Degree Relatives share 50% of genes
      1. Children
      2. Parents
      3. Siblings
    2. Second Degree Relatives share 25% of genes
      1. Aunts and Uncles
      2. Neices and nephews
      3. Grandparents
      4. Half-siblings
    3. Third Degree Relatives share 12.5% of genes
      1. First Cousins
      2. Great Grandparents
  2. Quick Family History for common diseases
    1. Coronary Artery Disease
    2. Cerebrovascular Accident
    3. Diabetes Mellitus
    4. Breast Cancer
    5. Ovarian Cancer
    6. Colon Cancer
  3. Single Gene Diseases
    1. Hemochromatosis (HFE)
    2. Tuberous Sclerosis (TS1, TS2)
    3. Autosomal Dominant Polycystic Kidney Disease (ADPKD1-2)
    4. Hereditary Hemorrhagic Telangiectasia (ENG, ACVRL1)
    5. Idiopathic Pulmonary Hypertension (BMPR2)
    6. Long QT Syndrome
    7. Factor V Leiden or APC Resistance
    8. Alpha-1-antitrypsin Deficiency (SERPINA)
    9. Glaucoma (MYOC)
    10. Hereditary Pancreatitis (PTSS1)
  4. Resources
    1. U.S. Surgeon General's Family History Initiative
      1. http://www.hhs.gov/familyhistory
  5. References
    1. Wattendrof (2005) Am Fam Physician 72(3):441

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