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ThiamineAka: Vitamin B1

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  1. Dietary Sources
    1. Pork
    2. Liver
    3. Oysters
    4. Whole-grain and enriched cereals, Pasta, Bread
    5. Wheat germ
    6. Oatmeal
    7. Peas
    8. Lima Beans
  2. Conditions associated with Deficiency
    1. Beriberi

Thiamine (C0039840)

Definition (MSH)3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
Definition (CSP)water soluble B vitamin with a structure consisting of substituted pyrimidine and thiazolium rings linked by a methylene group; deficiency causes beriberi.
Definition (PDQ)A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37856&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=37856&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C874" NCI Thesaurus)
Definition (NCI)A heat-labile and water-soluble essential vitamin, belonging to the vitamin B family, with antioxidant, erythropoietic, mood modulating, and glucose-regulating activities. Thiamine reacts with adenosine triphosphate (ATP) to form an active coenzyme, thiamine pyrophosphate. Thiamine pyrophosphate is necessary for the actions of pyruvate dehydrogenase and alpha-ketoglutarate in carbohydrate metabolism and for the actions of transketolase, an enzyme that plays an important role in the pentose phosphate pathway. Thiamine plays a key role in intracellular glucose metabolism and may inhibit the action of glucose and insulin on arterial smooth muscle cell proliferation. Thiamine may also protect against lead toxicity by inhibiting lead-induced lipid peroxidation.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121) , Vitamin (T127)
MSHD013831
EnglishAneurin, Anti-beriberi factor, B1 Vitamin, thiamin, Thiamine, Thiamine preparation, Vit B1, Vitamin B 1, VITAMIN B A 01, Vitamin B<sub>1</sub>, Vitamin B<sub>1</sub> preparation, Vitamin B>1<, Vitamin B>1< preparation, Vitamin B1, VITAMIN B1 PREPARATION, Vitamin-B1
Spanishfactor anti - beriberi, pirofosfato de tiamina, preparado con tiamina, preparado con vitamina B<sub>1</sub>, preparado con vitamina B>1<, preparado con vitamina B1, tiamina, vitamina B<sub>1</sub>, vitamina B>1<, vitamina B1
Parent ConceptsVitamin B Complex (C0042849), Thiazoles (C0039859), Pyrimidines (C0034289), B Vitamin Family (C1704763), Thiamine (C0039840), Unclassified Ingredient Preparations (C1377282), Ambiguous concept (C1274012), Drug allergen (C1320237)
SourcesAOD, CSP, LNC, MSH, MTH, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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