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Conenzyme Q10Aka: Ubiquinone, CoQ, Vitamin Q10, 2,3 Dimethoxy-5-Methyl-6-Decaprenyl Benzoquinone

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  1. Background
    1. Fat-soluble, vitamin-like quinone
    2. Endogenous compound used in energy metabolism
    3. Highest concentrations in heart, brain, liver, kidney
    4. Activity
      1. Central to electron transfer in ATP production
      2. Antioxidant scavenger
      3. Decreases calcium overload
      4. Protective against ischemia in CHF
  2. Indications: Neurologic
    1. Parkinsonism (360-1200 mg PO daily)
      1. Shults (2002) Arch Neurol 59:1541
    2. Migraine Headaches (150-300 mg PO daily)
      1. Sandor (2005) Neurology 64:713
  3. Indications: Cardiovascular (50-200 mg/day)
    1. Congestive Heart Failure (CHF) - unclear benefit
    2. Hypertension - insufficient evidence
    3. Coronary Artery Disease - experimental
  4. Indications: Miscellaneous
    1. Diabetes Mellitus (100-200 mg/day) - unclear benefit
  5. Adverse effects
    1. Gastrointestinal upset
    2. Potential risk of Hypoglycemia, hypotension
  6. Disadvantages
    1. Expensive: (1200 mg/day costs $300/month)
  7. References
    1. Bonakdar (2005) Am Fam Physician 72:1065

coenzyme Q10 (C0056077)

Definition (NCI)A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme Q10 functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme Q10 may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. (NCI04)
Definition (PDQ)A naturally occurring benzoquinone important in electron transport in mitochondrial membranes. Coenzyme-Q functions as an endogenous antioxidant; deficiencies of this enzyme have been observed in patients with many different types of cancer and limited studies have suggested that coenzyme-Q may induce tumor regression in patients with breast cancer. This agent may have immunostimulatory effects. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39187&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39187&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C916" NCI Thesaurus)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC024989
EnglishCo-Q10, coenzyme Q10, COENZYME Q10 PREPARATION, coenzyme-Q10, CoQ 10, CoQ10, Ubidecarenone, Ubiquinone, ubiquinone 50, ubiquinone Q10
Spanishcoenzima Q10, ubidecarenona
Parent ConceptsAntioxidants (C0003402), Quinones (C0034435), Unclassified Ingredients (C1372954), Unclassified Ingredient Preparations (C1377282), Coenzymes (C0009235), Inotropic agent (C0304509), Quinone and derivatives (C0578483), Drug allergen (C1320237), Alternative medicine preparation (C1527378), Alternative medicine agent (C1626216)
SourcesMSH, MTH, MTHFDA, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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