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Cytochrome P-450 2C9 IsoenzymeAka: CYP2C9
- Precautions: CYP2C9 Deficiency related to Warfarin toxicity
- Higher risk for Warfarin toxicity and bleeding complications
- Reaching a steady-state INR on Warfarin requires >3 months
- Voora (2005) Thromb Haemost 93:700
- Interactions: Metabolized by CYP2C9 (Substrates)
- Cardiopulmonary Drugs
- Carvedilol (Coreg)
- Tolbutamide
- Angiotensin Receptor Blockers (ARBs) affected
- ARBs not affected by Cytochrome P450 System
- Miscellaneous
- Cardiopulmonary Drugs
- Interactions: Inhibitor of CYP2C9
- Neuropsychiatric drugs
- Cardiopulmonary Drugs
- Amiodarone
- Zafirlukast (Accolate)
- Fluvastatin (Lescol)
- Antibiotics
- Fluconazole (Diflucan)
- Ketoconazole
- Metronidazole (Flagyl)
- Ritonavir
- Trimethoprim-sulfamethoxazole (Septra)
- Interactions: Inducer of CYP2C9
- Neuropsychiatric drugs
- Carbamazepine
- Phenobarbital
- Phenytoin
- Antibiotics
- Neuropsychiatric drugs
CYP2C9 protein, human (C0608437) | |
|---|---|
| Definition (NCI) | Induced by rifampin and expressed in liver by polymorphic human CYP2C9 Gene (CYP450 Family), 490-aa 56-kD Cytochrome P450 2C9 localizes to the endoplasmic reticulum membrane and oxidizes steroids, fatty acids, and xenobiotics in drug metabolism and in the synthesis of cholesterol, steroids and other lipids. |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Enzyme (T126) |
| MSH | C450260 |
| English | CYP 2C9, CYP2C9, CYP2C9 Protein, CYPIIC9, Cytochrome P 450 CYP2C9, Cytochrome P-450 CYP2C9, Cytochrome P450 2C9, EC 1.14.14.1, Flavoprotein-Linked Monooxygenase, Mephenytoin 4-Hydroxylase, Microsomal Monooxygenase, P-450MP, P450 MP-4, P450 PB-1, S-Mephenytoin 4-Hydroxylase, Xenobiotic Monooxygenase |
| Parent Concepts | Cytochrome P450 (C0010762) |
| Sources | MSH, MTH, NCI, NDFRT Derived from the NIH UMLS (Unified Medical Language System) |
