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Cytochrome P-450 2C19 IsoenzymeAka: CYP2C19

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  1. See Also
    1. CYP2C9
  2. Background
    1. CYP2C19 deficiency in 20% of asians (poor metabolizers)
  3. Interactions: Metabolized by CYP2C19 (Substrates)
    1. Neuropsychiatric drugs
      1. Clomipramine
      2. Imipramine
      3. Hexobarbital
      4. Mephobarbital
      5. Diazepam
      6. Phenobarbital
      7. Phenytoin
    2. Cardiopulmonary Drugs
      1. Propranolol (Inderal)
    3. Antibiotics
      1. Nelfinavir
    4. Miscellaneous
      1. Lansoprazole
      2. Pentamidine
      3. Felbamate
      4. Omeprazole (Prilosec)
  4. Interactions: Inhibitor of CYP2C19
    1. Neuropsychiatric drugs
      1. Fluvoxamine (Luvox)
    2. Antibiotics
      1. Isoniazid (INH)
      2. Ritonavir
    3. Miscellaneous
      1. Omeprazole (Prilosec)
      2. Cimetidine
  5. Interactions: Inducer of CYP2C19
    1. Neuropsychiatric Drugs
      1. Carbamazepine
      2. Phenytoin
    2. Antibiotics
      1. Rifampin

CYP2C19 protein, human (C0960580)

Definition (NCI)This protein is a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. (from LocusLink)
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSHC045793
EnglishCYP 2C19, CYP2C19, CYP2C19 Protein, CYPIIC17, CYPIIC19, Cytochrome P 450 CYP2C19, Cytochrome P-450 CYP2C19, Cytochrome P450 2C19, Cytochrome p450 CYP2C19 enzyme, EC 1.14.14.1, Flavoprotein-Linked Monooxygenase, Mephenytoin 4'-Hydroxylase, Mephenytoin 4-Prime-Hydroxylase, Microsomal Monooxygenase, P450-11A, P450-254C, Xenobiotic Monooxygenase
Spanishenzima CYP2C19 del citocromo p450
Parent ConceptsCytochrome P450 (C0010762), cytochrome P-450 CYP2C subfamily (C0910126)
SourcesMSH, MTH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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