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Cytochrome P-450 1A2 IsoenzymeAka: CYP1A2

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  1. Interactions: Metabolized by CYP1A2 (Substrates)
    1. Neuropsychiatric drugs
      1. Amitriptyline (Elavil)
      2. Clomipramine (Anafranil)
      3. Imipramine (Tofranil)
      4. Clozapine (Clozaril)
      5. Tacrine (Cognex)
    2. Cardiopulmonary Drugs
      1. Propranolol (Inderal)
      2. Theophylline
    3. Miscellaneous
      1. Acetaminophen (Tylenol)
      2. Caffeine
      3. Warfarin (Coumadin)
  2. Interactions: Inhibitor of CYP1A2
    1. Neuropsychiatric Drugs
      1. Fluvoxamine (Luvox)
      2. Tacrine (Cognex)
    2. Cardiopulmonary Drugs
      1. Verapamil
      2. Diltiazem
      3. Amiodarone (inhibitor)
    3. Antibiotics
      1. Enoxacin: Inhibitor
      2. Ciprofloxacin: Inhibitor
      3. Norfloxacin: Inhibitor
    4. Miscellaneous Drugs
      1. Grapefruit juice
      2. Cimetidine
      3. Ticlopidine
  3. Interactions: Inducers of CYP1A2
    1. Neuropsychiatric drugs
      1. Phenobarbital
      2. Phenytoin
    2. Antibiotics
      1. Rifampin
    3. Miscellaneous
      1. Charcoal broiled beef
      2. Tobacco exposure (e.g. Cigarette smoke)
      3. Cruciferous vegetables
      4. Omeprazole (Prilosec)

Cytochrome P-450 CYP1A2 (C0207509)

Definition (MSH)A cytochrome P-450 monooxygenase that can be induced by polycyclic aromatic xenobiotics in the liver of human and several animal species. This enzyme is of significant clinical interest due to the large number of drug interactions associated with its induction and its metabolism of THEOPHYLLINE. Caffeine is considered to be a model substrate for this enzyme. CYP1A2 activity can also be increased by environmental factors such as cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole.
Definition (NCI)A polycyclic aromatic hydrocarbon-inducible cytochrome which is of significant clinical interest due to the large number of drug interactions associated with induction and inhibition of theophylline. Caffeine is considered to be a model substrate for this enzyme. It also metabolizes theophylline and antipyrene. Environmental factors including cigarette smoking, charbroiled meat, cruciferous vegetables, and a number of drugs including phenytoin, phenobarbital, and omeprazole produce increases in CYP1A2 activity. (Ann Pharmacother 1995;29:619-24) EC 1.-.
ConceptsAmino Acid, Peptide, or Protein (T116) , Enzyme (T126)
MSHD019388
EnglishAryl Hydrocarbon Hydroxylase, Caffeine Demethylase, CYP 001 A 002, CYP 1A2, CYP1A2, CYTOCHROME P 450 CYP 001 A 002, Cytochrome P 450 CYP1A2, Cytochrome P 450d, Cytochrome P-450 CYP1A2, Cytochrome P-450 LM4, Cytochrome P-450d, Cytochrome P450 1A2, Cytochrome p450 CYP1A2 enzyme, Dioxin-Inducible P3-450, EC 1.14.14.1, Flavoprotein-Linked Monooxygenase, Microsomal Monooxygenase, P450 4, P450 Form 4, P450 orm 4, P450-P3, Phenacetin O Dealkylase, Phenacetin O-Dealkylase, Xenobiotic Monooxygenase
Spanishenzima CYP1A2 de citocromo p450
Parent ConceptsAryl Hydrocarbon Hydroxylases (C0003927), Cytochrome P450 (C0010762)
SourcesMSH, MTH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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