Pharmacology Book

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Genetic Determinants of Drug Response

Aka: Genetic Determinants of Drug Response, Pharmacogenomics, Pharmacogenetics
  1. Definition
    1. Genetic polymorphism as it relates to medication response
  2. Examples
    1. CYP2D6 Deficiency
      1. No response to codeine in 10% of patients
      2. Exaggerated response to Fluoxetine and Nortriptyline
    2. CYP2C9 Deficiency
      1. Higher risk of toxicity and bleeding complications
      2. Reaching a steady-state INR on Coumadin requires >3 months
    3. TPMT Deficiency
      1. Severe hematologic response to Azathioprine and mercaptopurine
    4. ADRB2 Variant
      1. Asthma status worsens on Inhaled Beta Agonist (e.g. Albuterol)
  3. References
    1. Evans (2003) N Engl J Med 348:538-49
    2. Lanfear (2007) Am Fam Physician 76:1179-82
    3. Meyer (2000) Lancet 356:1667-71

Pharmacogenetics (C0031325)

Definition (NCI) Study of the way drugs interact with genetic makeup or the study of genetic response to a drug.
Definition (NCI) The investigation of the influence of variations in DNA sequence on drug response.
Definition (NCI) The study of how a person's genes affect the way he or she responds to drugs. Pharmacogenetics is being used to learn ahead of time what the best drug or the best dose of a drug will be for a person.
Definition (MSH) A branch of genetics which deals with the genetic variability in individual responses to drugs and drug metabolism (BIOTRANSFORMATION).
Definition (CSP) branch of genetics (the branch of science concerned with the means and consequences of transmission and generation of the components of biological inheritance) which deals with the genetic variability in individual responses to drugs and drug metabolism.
Concepts Biomedical Occupation or Discipline (T091)
MSH D010597
Swedish Farmakogenetik
English PHARMACOGENET, pharmacogenetics, PGt, Pharmacogenetics, pharmacogenetic
Czech farmakogenetika
Finnish Farmakogenetiikka
French Pharmaco-génétique, Pharmacogénétique
Russian FARMAKOGENETIKA, ФАРМАКОГЕНЕТИКА
Croatian FARMAKOGENETIKA
Polish Farmakogenetyka
German Pharmakogenetik
Italian Farmacogenetica
Dutch Farmacogenetica
Portuguese Farmacogenética
Spanish Farmacogenética, Farmacogenetica
Sources
Derived from the NIH UMLS (Unified Medical Language System)


Pharmacogenomics Domain (C1882354)

Definition (NCI) A subject domain utilized for the submission of information encompassing and representing data, vocabulary or records related to pharmacogenomics.
Definition (NCI) Pharmacogenomics findings that initially focus on genotype and gene expression data.
Concepts Idea or Concept (T078)
English PG, Pharmacogenomics, Pharmacogenomics Domain
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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