II. Preparations: Diclofenac

  1. Diclofenac Solution (Pennsaid 1.5%)
  2. Diclofenac Gel (Voltaren Gel 1.5%)
  3. Diclofenac Patch (Flector Patch)

III. Preparations: Other NSAIDs

  1. Pharmacy may compound other NSAIDs (e.g. ketoprofen, piroxicam, Ibuprofen)

IV. Dosing: Diclofenac 1% gel applied to affected joints

  1. Measure gel on a dosing card and massage into affected area
  2. Overall maximum: 32 grams/day over all affected joints
  3. Elbow, hand or wrist: 2 grams applied up to 4 times daily (maximum 8 grams/day/joint)
  4. Knee, ankle or foot: 4 grams applied up to 4 times daily (maximum 16 grams/day/joint)

V. Precautions

  1. Despite low absorption, cardiovascular and renal risks may still pertain to Topical NSAIDs
  2. Do not combine with other topicals or other NSAID forms
  3. Do not apply heat to application site
  4. Avoid washing area or showering for at least one hour after application

VI. Pharmacokinetics

  1. Systemic absorption <10% (gel may be 6%)

VII. Adverse effects

  1. Local skin reactions

VIII. Efficacy

  1. Canadian study demonstrated equivalent efficacy to oral agent for specific Joint Pain

IX. Contraindications

  1. Absolute
    1. CABG history
    2. Asthma or Aspirin hypersensitivity
    3. Advanced renal disease
  2. Relative (use with caution in this group)
    1. Known cardiovascular disease
    2. Known Peptic Ulcer Disease (however topical diclofenac did not appear to increase ulcer risk)
    3. Hypertension (however topical diclofenac did not appear to increase Blood Pressure)
    4. Hepatic insufficiency
    5. Advanced Chronic Kidney Disease
    6. Congestive Heart Failure or other edematous condition

X. References

  1. (2016) Presc Lett 23(1): 2

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Cost: Medications

pennsaid (on 12/30/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
PENNSAID 2% PUMP $19.65 per gram

Ontology: Diclofenac Topical Product (C0358504)

Concepts Clinical Drug (T200)
SnomedCT 349350007
English Topical diclofenac, diclofenac topical, Diclofenac Topical Product, Topical form diclofenac (product), Topical form diclofenac, Topical diclofenac (product), Topical diclofenac (substance)
Spanish diclofenaco, forma farmacéutica tópica (producto), diclofenac tópico, diclofenaco, forma farmacéutica tópica, diclofenac tópico (producto)