II. Indications

  1. Narcotic Toxicity requiring frequent Naloxone dosing

III. Precautions

  1. Do not use as first line agent for Narcotic Toxicity
  2. Risk of severe Narcotic Withdrawal

IV. Pharmacokinetics

  1. Long acting Opioid antagonist
  2. Duration: 4-8 hours

V. Dosing

  1. Opioid Overdose
    1. Initial: 0.5 mg per 70 kg person IV
    2. Later: 1 mg per 70 kg IV prn 5 min after initial dose
    3. Narcotic dependent: 0.1 mg per 70 kg test dose
  2. Post-operative Narcotic reversal
    1. Dose: 0.25 ug/kg IV q2-5 minutes
    2. Maximum: 1 ug/kg total dose

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Ontology: nalmefene (C0068377)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C038981
SnomedCT 109098006
English 6-desoxy-6-methylenenaltrexone, nalmefene, NALMEFENE, nalmefene [Chemical/Ingredient], Nalmefene (substance), Nalmefene
Spanish nalmefeno (sustancia), nalmefeno

Ontology: Revex (C0723050)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C038981
English Revex, nalmefene hydrochloride (Revex), revex