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Nalmefene

Aka: Nalmefene, Revex

Indications
1. Narcotic Toxicity requiring frequent Naloxone dosing
Precautions
1. Do not use as first line agent for Narcotic Toxicity
2. Risk of severe Narcotic Withdrawal
Pharmacokinetics
1. Long acting Opioid antagonist
2. Duration: 4-8 hours
Dosing
1. Opioid Overdose
  1. Initial: 0.5 mg per 70 kg person IV
  2. Later: 1 mg per 70 kg IV prn 5 min after initial dose
  3. Narcotic dependent: 0.1 mg per 70 kg test dose
2. Post-operative Narcotic reversal
  1. Dose: 0.25 ug/kg IV q2-5 minutes
  2. Maximum: 1 ug/kg total dose

Revex (C0723050)
Concepts	Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH	C038981
English	Revex, nalmefene hydrochloride (Revex), revex
Sources	Derived from the NIH UMLS (Unified Medical Language System)

nalmefene (C0068377)
Concepts	Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH	C038981
SnomedCT	109098006
English	6-desoxy-6-methylenenaltrexone, nalmefene, NALMEFENE, nalmefene [Chemical/Ingredient], Nalmefene (substance), Nalmefene
Spanish	nalmefeno (sustancia), nalmefeno
Sources	Derived from the NIH UMLS (Unified Medical Language System)

Family Practice Notebook

Patients should address specific medical concerns with their physicians.

Although access to this page is not restricted, the information found here is intended for use by medical providers.

This page was written by Scott Moses, MD, last revised on 10/21/2007 and last published on 2/5/2012.

This is one of 5663 pages in the Family Practice Notebook