II. Indications

  1. Insomnia
  2. Proposed for anxiety (inconclusive data)

III. Physiology

  1. Sedative effects related to Valeric Acid component

IV. Dosing: Insomnia (taken 30-120 minutes before bedtime)

  1. Best efficacy with continuous use >10-14 days
  2. Extract: 300-600 mg PO qhs
  3. Dried root: 2-3 grams in hot water 15 minutes PO qhs

V. Efficacy: Insomnia

VI. Adverse effects (uncommon)

  1. Sleepiness on awakening (associated with 900 mg dose)
  2. Headache
  3. Gastrointestinal upset
  4. Withdrawal symptoms when stopped
    1. May be similar to Benzodiazepine Withdrawal

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Ontology: VALEPOTRIATE (C0772179)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Valepotriate, VALEPOTRIATE