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Natural ProgesteroneAka: Dioscorea, Yam extract, Wild Yam

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  1. Mechanism
    1. Yams are among 600 species of Dioscorea family
    2. Yams have Estrogenic Activity in animals
    3. Diosgenin is derived from yams
      1. Natural Progesterone source
      2. Highest concentration of Disogenin in Mexican Yam
      3. Diosgenin not converted to Progesterone in humans
      4. Diosgenin converted in labs to Progesterone
  2. Current Uses
    1. Premenstrual Syndrome
    2. Menopausal symptoms
    3. Osteoporosis
  3. Dosing: Natural Progesterone cream (not yam extract)
    1. Preparation: 400 mg per ounce
    2. Apply 1/4 to 1/2 teaspoon to vagina per day
  4. Efficacy
    1. Yams
      1. Yam extract has no Progesterone activity in humans
      2. Yam Estrogen levels are not high enough for benefit
    2. Natural Progesterone derived from Diosgenin
      1. May relieve some post-menopausal symptoms
      2. Minimal or no benefit in Osteoporosis
  5. Adverse Effects
    1. Yams are an unopposed Estrogen source
      1. Risk of Endometrial Cancer
      2. May require Endometrial Biopsy

Wild yam extract (C0772357)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishWILD YAM, Wild yam extract
SourcesMTH, RXNORM, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Genus Dioscorea (C0936043)

Definition (MSH)A plant genus best known for edible underground tubers. Yam may also refer to a moist variety of sweet potato, IPOMOEA BATATAS.
ConceptsPlant (T002)
MSHD027742
EnglishBorderea, Dioscorea, Dioscorea L., Genus Dioscorea, Nanarepenta, Tamus, Yam
Parent ConceptsDioscoreaceae (C0949812)
SourcesMSH, MTH, NCBI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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