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MyoinositolAka: Inositol

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  1. Physiology
    1. Simple carbohydrate metabolized to Phosphatidylinositol
    2. Acts as second messenger to stimulate calcium release
    3. No known deficiency states in humans
  2. Indications
    1. Anxiety Disorder
      1. Panic Disorder
      2. Obsessive Compulsive Disorder (possibly)
    2. Other purported benefits
      1. May improve neural function in Diabetes Mellitus
  3. Preparations: Dietary sources (B Vitamin Complex part)
    1. Beans
    2. Citrus fruit
    3. Nuts
    4. Rice
    5. Veal
    6. Pork
    7. Wheat germ
  4. Dosing
    1. Panic Disorder: 12-18 grams daily
  5. Efficacy
    1. Effective in Panic Disorder
      1. Benjamin (1995) Am J Psychiatry 152:1084
      2. Palatnik (2001) J Clin Psychopharmacol 21:335
    2. Possibly effective in Obsessive-Compulsive Disorder
      1. Fux (1996) Am J Psychiatry 153:1219

Inositol (C0021547)

Definition (MSH)An isomer of glucose that has traditionally been considered to be a B vitamin although it has an uncertain status as a vitamin and a deficiency syndrome has not been identified in man. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1379) Inositol phospholipids are important in signal transduction.
Definition (CSP)cyclic sugar alcohol, the fully hydroxylated derivative of cyclohexane, occurring naturally in a variety of stereoisomers, most commonly, the myo-isomer, myoinositol, a member of the vitamin B complex and a component of phosphatidylinositols.
Definition (NCI)A type of sugar that differs from glucose (the chief source of energy for living organisms) in its chemical structure. Certain modified forms of inositol can be used by the body to transmit signals inside and between cells.
Definition (PDQ)A natural sugar found in cell membrane phospholipids, plasma lipoproteins, and (as the phosphate form) in the nucleus with potential chemopreventive properties. As one of a number of intracellular phosphate compounds, inositol is involved in cell signaling and may stimulate tumor cell differentiation. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=305828&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=305828&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C28163" NCI Thesaurus)
Definition (NCI)A natural sugar found in cell membrane phospholipids, plasma lipoproteins, and (as the phosphate form) in the nucleus with potential chemopreventive properties. As one of a number of intracellular phosphate compounds, inositol is involved in cell signaling and may stimulate tumor cell differentiation. (NCI04)
ConceptsCarbohydrate (T118) , Pharmacologic Substance (T121) , Vitamin (T127)
MSHD007294
EnglishAnti-alopecia factor, Chiro Inositol, Chiro-Inositol, Cyclohexanehexol, Inose, Inositol, Inositol product, Mesoinositol, myo-inositol, Myoinositol
Spanishfactor antialopecia, inosa, inositol, preparado con inositol, preparado de inositol
Parent ConceptsSugar Alcohols (C0038654), Second Messenger Systems (C0036522), Vitamin B Complex (C0042849), Inactive Ingredient Preparations (C1375189), Lipotropic Agents (C0023831), Duplicate concept (C1274013)
SourcesAOD, CSP, LCH, LNC, MSH, MTH, MTHFDA, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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