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Milk ThistleAka: Silybum marianum, Silymarin
- Uses
- Liver disease (Cirrhosis, Hepatitis)
- Mixed results in clinical trials
- Amanita phalloides poisoning
- Insufficient evidence to date
- Liver disease (Cirrhosis, Hepatitis)
- Investigational
- Cytoprotection (environmental hazards, Chemotherapy)
- Anticarcinogen
- Adverse Effects
- Mild gastrointestinal upset
- Drug Interactions
- No significant interactions
- Dosing
- Optimal dosing not yet established
- References
Silymarin (C0037135) | |
|---|---|
| Definition (MSH) | A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent. |
| Definition (PDQ) | A mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=284684&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=284684&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26671" NCI Thesaurus) |
| Definition (NCI) | A mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. (NCI04) |
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) |
| MSH | D012838 |
| English | Silimarin, Silymarin |
| Parent Concepts | Flavonolignans (C1257967), Antioxidants (C0003402), Hepatoprotective Agent (C1512412) |
| Sources | MSH, NCI, PDQ, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
Milk Thistle (C0331428) | |
|---|---|
| Definition (MSH) | The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L. |
| Concepts | Plant (T002) |
| MSH | D020944 |
| English | Carduus marianus, Carduus marianus L., holy thistle, lady's thistle, Milk Thistle, Silybum marianum, Variegated thistle |
| Spanish | cardo jaspeado |
| Parent Concepts | Asteraceae (C0446228), Silybum (C0331427) |
| Sources | MSH, MTH, NCBI, SCTSPA, SNOMEDCT Derived from the NIH UMLS (Unified Medical Language System) |
