II. Uses

  1. Liver disease (Cirrhosis, Hepatitis)
    1. Mixed results in clinical trials
  2. Amanita phalloides Poisoning
    1. Insufficient evidence to date

III. Investigational

  1. Cytoprotection (environmental hazards, Chemotherapy)
  2. Anticarcinogen

IV. Adverse Effects

  1. Mild gastrointestinal upset

V. Drug Interactions

  1. No significant interactions

VI. Dosing

  1. Optimal dosing not yet established

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Ontology: Silymarin (C0037135)

Definition (NCI) A mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. (NCI04)
Definition (NCI_NCI-GLOSS) A substance obtained from milk thistle seeds that is being studied in the prevention of liver damage caused by certain cancer treatments.
Definition (MSH) A mixture of flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum. It consists primarily of silybin and its isomers, silicristin and silidianin. Silymarin displays antioxidant and membrane stabilizing activity. It protects various tissues and organs against chemical injury, and shows potential as an antihepatoxic agent.
Definition (PDQ) A mixture of flavonolignans isolated from the milk thistle plant Silybum marianum. Silymarin may act as an antioxidant, protecting hepatic cells from chemotherapy-related free radical damage. This agent may also promote the growth of new hepatic cells. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=284684&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=284684&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C26671" NCI Thesaurus)
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D012838
English Silimarin, Silymarin, Silymarin [Chemical/Ingredient], silimarin, silymarin
Swedish Silimarin
Czech silymarin
Finnish Silymariini
Russian LEGALON, SILIBININ, KARSIL, SILIBIN, SILIMARIN, КАРСИЛ, ЛЕГАЛОН, СИЛИБИН, СИЛИБИНИН, СИЛИМАРИН
Japanese シリビニン, シリビン, シリマリン
Polish Silymarin
French Silymarine
German Silymarin
Italian Silimarina
Portuguese Silimarina
Spanish Silimarina

Ontology: Milk Thistle (C0331428)

Definition (NCI_NCI-GLOSS) A plant whose leaves, stems, and flowers have been used in some cultures to treat certain medical problems. Spotted thistle may have anti-inflammatory and anticancer effects. The scientific name is Cnicus benedictus.
Definition (MSH) The plant Silybum marianum in the family ASTERACEAE containing the bioflavonoid complex SILYMARIN. For centuries this has been used traditionally to treat liver disease. Silybum marianum (L.) Gaertn. = Carduus marianus L.
Concepts Plant (T002)
MSH D020944
SnomedCT 64951005
English Silybum marianum, Variegated Thistle, Spotted Thistle, Blessed Milkthistle, Mariana mariana (L.) Hill, Milk Thistle, marianus, Carduus, Milk Thistles, Thistle, Milk, Thistles, Milk, Silybum marianums, marianum, Silybum, marianums, Silybum, carduus marianus, milk thistles, silybum marianum, milk thistle, Carduus marianus, Milk thistle, spotted thistle, SILYBUM MARIANUM WHOLE, Variegated thistle, Silybum marianum (organism), holy thistle, lady's thistle, Carduus marianus L.
Swedish Mariatistel
Czech Silybum marianum, ostropestřec mariánský
Finnish Kaalivalvatti
Italian Carduus marianus, Silybum marianum, Cardo mariano
Russian RASTOROPSHA, SILYBUM MARIANUM, CARDUUS MARIANUS, РАСТОРОПША
Japanese オオアザミ, マリヤアザミ
French Chardon argenté, Chardon de Notre-Dame, Chardon-Marie, Silybe de Marie, Lait de Notre-Dame, Carduus marianus, Silybium marianum
Polish Ostropest plamisty, Pstrok
Norwegian Silybum marianum, Maritistel, Carduus marianus, Mariatistel
Portuguese Serralha de Folhas Pintadas, Cardo Mariano, Carduus marianus, Silybum marianum
Spanish Silybum marianum (organismo), cardo jaspeado, Silybum marianum, Cardo Lechero, Carduus marianus
German Mariendistel, Silybum marianum, Carduus marianus
Dutch Distel, Maria-, Mariadistel, Silybum marianum, Carduus marianus