II. Background

  1. Not recommended due to serious adverse effects and lack of efficacy data

III. Pharmacology

  1. From plant-derived flavinoids

IV. Indications

  1. Promoted and sold as a medical food for Osteoarthritis

V. Efficacy

  1. No evidence of benefit

VI. Adverse Effects

  1. Acute Hepatitis
    1. Occurs in 1:10,000 patients
    2. Resolves on stopping Limbrel
  2. Hypersensitivity pneumonitis

VII. References

  1. (2012) Presc Lett 19(9): 51

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