II. Indications (Purported uses)

  1. Migraine Headache prevention

III. Efficacy

  1. Some studies support benefit for Migraine prevention
  2. No benefit in Rheumatoid Arthritis

IV. Mechanism

  1. Inhibits prostaglandin synthesis
  2. Serotonin antagonist
  3. Inhibits platelet aggregation

V. Dosing

  1. Standard extract 125 mg (at least 0.2% parthenolide)

VI. Adverse Effects

VII. Contraindications

  1. Pregnancy
    1. Feverfew may induce menstruation
  2. Concurrent Anticoagulant use or peri-operative
    1. Feverfew increases bleeding risk

VIII. References

  1. Shaughnessy (1997) Fam Practice Recert 19(10):53-6
  2. Zink (1998) Am Fam Physician 58(5): 1133-40 [PubMed]

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Ontology: feverfew extract (C0376266)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
English Feverfew Extract, feverfew extract, feverfew (medication), Tanacetum Parthenium, Feverfew, TANACETUM PARTHENIUM, feverfew, FEVERFEW, Tanacetum parthenium extract, FEVERFEW EXTRACT