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Don QuaiAka: Dong Quai, Angelica sinensis

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  1. Current uses
    1. Premenstrual Syndrome
    2. Irregular Menses
    3. Infertility
    4. Menopause
  2. Contraindications
    1. Anticoagulant medication
    2. Bleeding Diathesis (natural coumarins)
  3. Efficacy
    1. Herb no better than Placebo for menopausal symptoms
      1. Double-blind Placebo control (n=71 postmenopausal)
      2. Dong Quai 1.5 g tid for 24 weeks
    2. References
      1. Hirata (1997) Fertil Steril 68:981
  4. Adverse Effects
    1. Psoralen effects
      1. Photosensitization
      2. Dermatitis
    2. Coumarin-like derivatives
      1. May increase bleeding risk

Angelica sinensis (C0950081)

Definition (MSH)A plant species of the family APIACEAE that is the source of dong quai.
ConceptsPlant (T002)
MSHD029971
EnglishAngelica sinensis, Chinese angelica, dong gui, dong quai
Parent ConceptsAngelica (C0936217)
SourcesMSH, MTH, NCBI
Derived from the NIH UMLS (Unified Medical Language System)


Angelica sinensis preparation (C1122975)

Definition (PDQ)An herbal extract derived from the root of the plant Angelica sinensis with possible antiinflammatory, antispasmodic, vasodilatory, estrogenic, and antitumor activities. Angelica sinensis contains volatile oils, including safrole, isosafrole, and n-butylphthalide; coumarin derivatives, including psoralens, bergapten, osthol, imperatorin, and oxypeucedanin; and ferulic acid. The coumarin derivatives in this agent may vasodilate and relax smooth muscle and may exhibit additive anticoagulant effects. Ferulic acid, a phenolic phytochemical present in plant cell walls, may neutralize free radicals such as reactive oxygen species.In addition, Angelica sinensis extract has been shown to inhibit the growth and induce apoptosis of glioblastoma mutltiforme brain tumor cells through p53-dependent and p53-independent pathways. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=467927&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=467927&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C60817" NCI Thesaurus)
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC109695
EnglishAngelica sinensis extract, Angelica sinensis preparation, dong quai, Dong quai extract, DONG QUAI PREPARATION
Spanishextracto de Angelica sinensis
Parent ConceptsUnclassified Ingredients (C1372954), Unclassified Ingredient Preparations (C1377282), Plant product (C0032088), Drug allergen (C1320237)
SourcesMSH, MTH, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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