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ChondroitinAka: Chondroitin sulfate

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  1. Indications
    1. Osteoarthritis (not recommended)
  2. Mechanism
    1. Endogenous glycosaminoglycan contained in joint matrix
  3. Efficacy: Does not appear effective for Osteoarthritis
    1. Effect requires at least one month of therapy
    2. Recent large studies suggest that chondroitin is not effective
      1. Initially appeared more effective than Placebo at relieving pain
      2. Adding Chondroitin to Glucosamine does not offer significant benefit
    3. References
      1. Reichenbach (2007) Ann Intern Med 146:580
  4. Source
    1. Animal sources such as shark and cow cartilage
      1. Theoretical risk of animal disease contamination
  5. Dosing
    1. Chondroitin 400 mg orally three time daily
  6. Adverse Effects
    1. Well tolerated
    2. Gastrointestinal upset
  7. References
    1. Leeb (2000) J Rheumatol 27:205
    2. McAlindon (2000) JAMA 283:1469

Chondroitin (C0008454)

Definition (MSH)A mucopolysaccharide constituent of chondrin. (Grant & Hackh's Chemical Dictionary, 5th ed)
Definition (CSP)family of acetylgalactosamine mucopolysaccharides.
ConceptsCarbohydrate (T118) , Pharmacologic Substance (T121) , Biologically Active Substance (T123)
MSHD002807
EnglishChondroitin, CHONDROITIN PREPARATION
Parent ConceptsGlycosaminoglycans (C0017973), [TN900] THERAPEUTIC NUTRIENTS/MINERALS/ELECTROLYTES, OTHER (C0973661)
SourcesCSP, MSH, NCI, NDFRT, RXNORM, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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