II. Definition

  1. Congenital syndrome due to in-utero Phenytoin exposure

III. Epidemiology

  1. Incidence: <10% of exposed fetuses

IV. Signs

  1. Microcephaly
  2. Growth Delay
  3. Mental Retardation and Developmental Delay
  4. Craniofacial dysmorphic features
    1. Flat Nasal Bridge
    2. Epicanthic folds
    3. Prominent upper lip over wide mouth
  5. Distinguishing characteristics
    1. Nail and distal phalanx hypoplasia
    2. Hypertelorism

V. Differential Diagnosis

VI. References

  1. Gabbe (2002) Obstetrics, Churchill, p. 225
  2. Ellenhorn (1997) Medical Toxicology, Williams, p. 606

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