Obstetrics Book

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Fetal Hydantoin Syndrome

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  1. See Also
    1. Teratogen
    2. Phenytoin
  2. Definition
    1. Congenital syndrome due to in-utero Phenytoin exposure
  3. Epidemiology
    1. Incidence: <10% of exposed fetuses
  4. Signs
    1. Microcephaly
    2. Growth delay
    3. Mental retardation and developmental delay
    4. Craniofacial dysmorphic features
      1. Flat nasal bridge
      2. Epicanthic folds
      3. Prominent upper lip over wide mouth
    5. Distinguishing characteristics
      1. Nail and distal phalanx hypoplasia
      2. Hypertelorism
  5. Differential Diagnosis
    1. Fetal Alcohol Syndrome
  6. References
    1. Gabbe (2002) Obstetrics, Churchill, p. 225
    2. Ellenhorn (1997) Medical Toxicology, Williams, p. 606

Fetal hydantoin syndrome (C0265372)

ConceptsCongenital Abnormality (T019) , Disease or Syndrome (T047)
EnglishFetal hydantoin syndrome, Fetal phenytoin syndrome, FHS, Meadow's syndrome
Spanishsindrome fetal por hidantoina
Parent ConceptsMultiple malformation syndrome due to non-infectious environmental agents (C0265370), Congenital anomalies of fetus (C0266647), Fetus or neonate affected by placental or breast transfer of anticonvulsant (C0411195), Congenital malformation syndrome due to known exogenous cause (C0452132), Drug-related disorder (C0277579), Duplicate concept (C1274013)
SourcesMTH, OMIM, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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