Obstetrics Book

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Vaginal Fluid pHAka: Nitrazine Paper, Nitrazine

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  1. See Also
    1. Premature Rupture of Membranes
    2. Ferning of Vaginal Fluid
    3. Vaginal Pooling
  2. Indications
    1. Evaluation for Premature Rupture of Membranes
  3. Mechanism
    1. Nitrazine paper relies on Prussian blue reaction
    2. Requires alkaline paper to cause reaction
  4. Technique
    1. Obtain fluid for exam (usually after Vaginal Pooling)
    2. Place Nitrazine paper in fluid
      1. Paper turns bright blue in alkaline fluid
  5. Interpretation: Nitrazine Paper
    1. Normal Vaginal pH 4.5-6.0: Paper does not change color
    2. Ruptured Vaginal pH 7.1-7.3: Suggests PROM (paper blue)
  6. Causes: False Positive Nitrazine positive (pH >7)
    1. Blood
    2. Semen
    3. Antiseptic solutions
    4. Urine with increased pH (alkaline urine)
    5. Vaginal infection (Bacterial Vaginosis)
  7. Efficacy
    1. Accuracy for amniotic fluid: 87-97%
  8. References
    1. Bennett (1993) Am J Perinatol 10(2):101

Nitrazine yellow (C0068806)

ConceptsOrganic Chemical (T109) , Indicator, Reagent, or Diagnostic Aid (T130)
MSHC013617
EnglishDNPNS, nitrazine paper, Nitrazine yellow, Nitrazine yellow stain, Nitrazol yellow, phenaphthazine
Spanishamarillo de nitrazina, colorante amarillo de nitrazina
Parent ConceptsReagents (C0034760), Tissue Stains (C0282157), Azo dye (C0301161)
SourcesMSH, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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