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Crouzon's Disease

See Also
1. Craniosynostosis
Epidemiology
1. Autosomal dominant: FGFR2 gene, chromosome 10
2. More than half of cases are new mutations
3. Incidence: 1 in 25,000 live births
4. Causes 5% of Craniosynostosis cases
Risk factors
1. Paternal age >35 years
2. Family History
Clinical findings
1. Brachycephaly (Craniosynostosis)
2. Hypertelorism
3. Proptosis
4. Maxillary Hypoplasia
5. Beaked nose
Associated conditions
1. Cleft Palate
2. Chiari 1 Malformation
3. Ear disorders
4. Cervical spine disorders
References
1. Johnston in Behrman (2004) Nelson Pediatrics, p. 1992-3
2. Kabbani (2004) Am Fam Physician 69:2863

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This page was written by Scott Moses, MD. This page was last revised before 5/10/08, prior to consistent tracking of revision date. This page was last published on 5/10/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 6.0.