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Pain SensationAka: Allodynia, Hyperpathia

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  1. Definitions
    1. Allodynia
      1. Nonpainful stimulus results in perception of pain
    2. Hyperpathia
      1. Pain out of proportion to pain stimulus

Hyperalgesia (C0020429)

Definition (MSH)An increased sensation to painful stimuli that may follow damage to soft tissue containing NOCICEPTORS or injury to a peripheral nerve. Hyperalgesia can occur both at the site of tissue damage (primary hyperalgesia) and in the surrounding undamaged areas (secondary hyperalgesia). (Kandel et al., Principles of Neural Science, 3d ed, p386)
Definition (CSP)excessive sensitivity to painful stimuli.
ConceptsFinding (T033)
MSHD006930
EnglishHyperalgesia, Hyperalgesias, Hyperalgesic Sensation, Hyperalgesic Sensations, Hyperalgia, Hyperpathia, Increased sensitivity to painful stimulus
Spanishhiperalgesia, hiperpatia
Parent ConceptsPain (C0030193), Nervous System Disorders, General and NEC (C0549573), Symptoms (C1457887), Somatosensory Disorders (C0752262), Hyperesthesia (C0020453), Decreased pain threshold (C0456440), Duplicate concept (C1274013)
SourcesCSP, CST, MSH, NCI, NDFRT, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Nociception (C0234194)

Definition (GO)The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. [http://www.onelook.com/]
Definition (NCI)The stimulus-response process involving the stimulation of peripheral pain-carrying nerve fibers (e.g., C-fibers, A-delta fibers) and the transmission of impulses along peripheral nerves of the central nervous system, where the stimulus is perceived as pain. (Taber's)
ConceptsOrganism Function (T040)
EnglishAbility to sense pain, Nociception, pain perception, Pain sensation, perception of physiological pain, sensory perception of pain
Spanishcapacidad de sentir dolor, capacidad para sentir dolor, sensacion de dolor
Parent Conceptssomesthetic perception (C0679031), Esthesia (C0036658), Sensory Process (C1327511), Sensory function (C0423552), Ambiguous concept (C1274012), Sensation observable (C1285607), Pain observable (C1320390)
SourcesAOD, CSP, GO, MTH, NCI, SCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)


Allodynia (C0458247)

ConceptsFinding (T033)
EnglishAllodynia, Painful response to non-painful stimulus
Spanishalodinia, respuesta dolorosa a estimulos no dolorosos
Parent ConceptsHyperesthesia (C0020453)
SourcesSCTSPA, SNOMEDCT
Derived from the NIH UMLS (Unified Medical Language System)



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