Neurology Book

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Oxcarbazepine

Aka: Oxcarbazepine, Trileptal
  1. Indications
    1. Simple Partial Seizures
    2. Complex Partial Seizures
    3. Generalized Tonic Clonic Seizures
    4. Trigeminal Neuralgia
    5. Mania
  2. Adverse Effects: Dose related
    1. Nausea or Vomiting
    2. Dizziness
    3. Ataxia
    4. Diplopia
    5. Sedation
    6. Lethargy
    7. Hyponatremia
    8. Tremor
  3. Adverse Effects: Other
    1. Hyponatremia
    2. Cardiac arrhythmia
  4. Dosing: Adults (includes elderly)
    1. Initial: 300 mg PO bid
    2. Increase by 600 mg/day weekly
    3. Target dose: 600 mg PO bid

Trileptal (C0876196)

Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C036006
English trileptal, Novartis brand of oxcarbazepine, Trileptal
Japanese オクスカルバゼピン
Sources
Derived from the NIH UMLS (Unified Medical Language System)


oxcarbazepine (C0069751)

Definition (NCI) A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121)
MSH C036006
SnomedCT 323042005, 116511002, 387025007
English oxcarbazepine, 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide, oxcarbazepine (medication), OXCARBAZEPINE, oxcarbazepine [Chemical/Ingredient], oxcarbazepine substance, OXcarbazepine, Oxcarbazepine (product), Oxcarbazepine (substance), Oxcarbazepine
Spanish Oxcarbazepine, oxcarbacepina, oxcarbazepina (producto), oxcarbazepina (sustancia), oxcarbazepina
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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