III. Adverse Effects: Dose related

IV. Adverse Effects: Other

  1. Hyponatremia
  2. Cardiac arrhythmia

V. Dosing: Adults (includes elderly)

  1. Initial: 300 mg PO bid
  2. Increase by 600 mg/day weekly
  3. Target dose: 600 mg PO bid

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Cost: Medications

oxcarbazepine (on 8/17/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
OXCARBAZEPINE 150 MG TABLET Generic $0.15 each
OXCARBAZEPINE 300 MG TABLET Generic $0.19 each
OXCARBAZEPINE 300 MG/5 ML SUSP Generic $0.46 per ml
OXCARBAZEPINE 600 MG TABLET Generic $0.40 each
trileptal (on 7/12/2016 at Medicaid.Gov Survey of pharmacy drug pricing)
TRILEPTAL 150 MG TABLET Generic $0.15 each
TRILEPTAL 300 MG TABLET Generic $0.19 each
TRILEPTAL 300 MG/5 ML SUSP Generic $0.46 per ml
TRILEPTAL 600 MG TABLET Generic $0.40 each

Ontology: oxcarbazepine (C0069751)

Definition (NCI) A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C036006
SnomedCT 323042005, 116511002, 387025007
LNC LP20805-5, MTHU012038
English 10,11-Dihydro-10-oxo-5H-dibenz(b,f)azepine-5-carboxamide, oxcarbazepine (medication), OXCARBAZEPINE, oxcarbazepine [Chemical/Ingredient], oxcarbazepine substance, OXcarbazepine, oxcarbazepine, Oxcarbazepine (product), Oxcarbazepine (substance), Oxcarbazepine
Spanish oxcarbacepina, oxcarbazepina (producto), oxcarbazepina (sustancia), oxcarbazepina

Ontology: Trileptal (C0876196)

Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH C036006
English trileptal, Novartis brand of oxcarbazepine, Trileptal
Japanese オクスカルバゼピン