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OxcarbazepineAka: Trileptal

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  1. Indications
    1. Simple Partial Seizures
    2. Complex Partial Seizures
    3. Generalized Tonic Clonic Seizures
    4. Trigeminal Neuralgia
    5. Mania
  2. Adverse Effects: Dose related
    1. Nausea or Vomiting
    2. Dizziness
    3. Ataxia
    4. Diplopia
    5. Sedation
    6. Lethargy
    7. Hyponatremia
    8. Tremor
  3. Adverse Effects: Other
    1. Hyponatremia
    2. Cardiac arrhythmia
  4. Dosing: Adults (includes elderly)
    1. Initial: 300 mg PO bid
    2. Increase by 600 mg/day weekly
    3. Target dose: 600 mg PO bid

oxcarbazepine (C0069751)

Definition (NCI)A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC036006
Englishoxcarbazepine, OXCARBAZEPINE PREPARATION
Spanishoxcarbacepina, oxcarbazepina
Parent ConceptsAnticonvulsants (C0003286), Carbamazepine (C0006949), Carbazepine antiepileptic (C0360123), Carbamazepine and derivatives (C1445633), Duplicate concept (C1274013), Sodium Channel Blockers (C0872271)
SourcesLNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)


Trileptal (C0876196)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHC036006
EnglishNovartis brand of oxcarbazepine, Trileptal
SourcesMSH, MTH, NCI, RXNORM
Derived from the NIH UMLS (Unified Medical Language System)



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