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OxcarbazepineAka: Trileptal

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  1. Indications
    1. Simple Partial Seizures
    2. Complex Partial Seizures
    3. Generalized Tonic Clonic Seizures
    4. Trigeminal Neuralgia
    5. Mania
  2. Adverse Effects: Dose related
    1. Nausea or Vomiting
    2. Dizziness
    3. Ataxia
    4. Diplopia
    5. Sedation
    6. Lethargy
    7. Hyponatremia
    8. Tremor
  3. Adverse Effects: Other
    1. Hyponatremia
    2. Cardiac arrhythmia
  4. Dosing: Adults (includes elderly)
    1. Initial: 300 mg PO bid
    2. Increase by 600 mg/day weekly
    3. Target dose: 600 mg PO bid

oxcarbazepine (C0069751)

Definition (NCI)A dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazepine is converted to its active metabolite, 10-monohydroxy. Although the mechanism of action has not been fully elucidated, electrophysiological studies indicate this agent blocks voltage-gated sodium channels, thereby stabilizing hyper-excited neural membranes, inhibiting repetitive neuronal firing, and decreasing the propagation of synaptic impulses.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
Englishoxcarbazepine, OXCARBAZEPINE PREPARATION
Spanishoxcarbacepina, oxcarbazepina
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Trileptal (C0876196)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishNovartis brand of oxcarbazepine, Trileptal
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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