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MethysergideAka: Sansert

Indications
1. Second line drug for Migraine Prophylaxis
2. Use only with Neurology consultation (due to toxicity)
Mechanism
1. Serotonin Antagonist (partial agonist activity)
Dosing
1. Sansert 4-8 mg PO qd
2. Drug holiday for 4 weeks every 6 months
Adverse Effects
1. Retroperitoneal fibrosis
2. Weight gain
3. Edema

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This page was written by Scott Moses, MD, and was last revised 1/27/2008. Please send comments and questions to the editor. Contact information may be found on the page About the Family Practice Notebook. These pages are best viewed with Microsoft Internet Explorer 5.0.