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Midodrine
- Indications
- Autonomic Neuropathy
- Mechanism
- Alpha agonist: constricts arterioles and veins
- Increases peripheral resistance
- Efficacy
- Study: n=162, PCT
- Significantly improved standing BP and symptoms
- Reference
- Low (1997) JAMA 277:1046
- Adverse Effects
- Pilomotor reactions
- Urinary urgency and retention
- Supine Hypertension
- Dosing
- Dose: 10 mg PO tid
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| Definition (MSH) | An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension. |
| Definition (NCI) | A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS). |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Midodrin, Midodrine, MIDODRINE PREPARATION |
| Spanish | midodrina |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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