II. Indications

III. Mechanism

  1. Alpha agonist: constricts arterioles and veins
  2. Increases peripheral resistance

IV. Efficacy

  1. Study: n=162, PCT
    1. Significantly improved standing BP and symptoms
  2. Reference
    1. Low (1997) JAMA 277:1046-51 [PubMed]

V. Adverse Effects

  1. Pilomotor reactions
  2. Urinary urgency and retention
  3. Supine Hypertension

VI. Dosing

  1. Dose: 10 mg PO tid

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Cost: Medications

midodrine (on 5/17/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
MIDODRINE HCL 10 MG TABLET Generic $0.85 each
MIDODRINE HCL 2.5 MG TABLET Generic $0.36 each
MIDODRINE HCL 5 MG TABLET Generic $0.53 each

Ontology: Midodrine (C0026078)

Definition (MSH) An ethanolamine derivative that is an adrenergic alpha-1 agonist. It is used as a vasoconstrictor agent in the treatment of HYPOTENSION.
Definition (NCI) A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
Concepts Pharmacologic Substance (T121) , Organic Chemical (T109)
MSH D008879
SnomedCT 108539003, 372504000
English Midodrin, Midodrine, Acetamide, 2-amino-N-(2-(2,5-dimethoxyphenyl)-2-hydroxyethyl)-, Midodrine [Chemical/Ingredient], midodrin, midodrine, MIDODRINE, Midodrine (product), Midodrine (substance)
Swedish Midodrin
Czech midodrin
Finnish Midodriini
Russian MIDODRIN, МИДОДРИН
Japanese ミドドリン
Polish Midodrin
Spanish midodrina (producto), midodrina (sustancia), midodrina, Midodrina
French Midodrine
German Midrodin
Italian Midodrina
Portuguese Midodrina