Neurology Book

http://www.fpnotebook.com/

Midodrine

Advertisement

  1. Indications
    1. Autonomic Neuropathy
  2. Mechanism
    1. Alpha agonist: constricts arterioles and veins
    2. Increases peripheral resistance
  3. Efficacy
    1. Study: n=162, PCT
      1. Significantly improved standing BP and symptoms
    2. Reference
      1. Low (1997) JAMA 277:1046
  4. Adverse Effects
    1. Pilomotor reactions
    2. Urinary urgency and retention
    3. Supine Hypertension
  5. Dosing
    1. Dose: 10 mg PO tid

Midodrine (C0026078)

Definition (MSH)An ethanolamine derivative that is an adrenergic alpha agonist. It is used as a vasoconstrictor agent in the treatment of hypotension.
Definition (NCI)A direct-acting prodrug and sympathomimetic agent with antihypotensive properties. Midodrine is converted to its active metabolite, desglymidodrine by deglycination reaction. Desglymidodrine selectively binds to and activates alpha-1-adrenergic receptors of the arteriolar and venous vasculature. This causes smooth muscle contraction and leads to an elevation of blood pressure. Desglymidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system (CNS).
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
MSHD008879
EnglishMidodrin, Midodrine, MIDODRINE PREPARATION
Spanishmidodrina
Parent ConceptsEthanolamines (C0014983), Adrenergic alpha-Agonists (C0001640), [CV900] CARDIOVASCULAR AGENTS, OTHER (C0991601), Sympathomimetics (C0039052)
SourcesMSH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



Navigation Tree