II. Indications

  1. Adjunctive agent in Refractory Partial-Onset Seizures
  2. Bipolar Disorder
  3. Trigeminal Neuralgia

III. Mechanism

  1. Antiepileptic
  2. Sodium channel blocker (similar to Carbamazepine and Oxcarbazepine)

IV. Dosing

  1. Normal Renal Function
    1. Initial: 400 mg orally once daily for 1 week
    2. Maintenance: 800 mg orally once daily
    3. Maximum dose: 1200 mg/day
  2. Decreased Renal Function to Creatinine Clearance <50 ml/min
    1. Initial: 200 mg orally once daily for 2 weeks
    2. Maintenance: 400 mg orally once daily
    3. Maximum dose: 600 mg/day

VI. Drug Interactions

  1. Do not use with other similar Sodium channel blocker agents such as Carbamazepine and Oxcarbazepine
  2. Hormonal contraceptives
    1. Eslicarbazepine decreases the contraceptive efficacy
    2. Use alternative, non-hormonal agents or backup Contraception

VIII. References

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Cost: Medications

aptiom (on 4/19/2017 at Medicaid.Gov Survey of pharmacy drug pricing)
APTIOM 200 MG TABLET $26.79 each
APTIOM 400 MG TABLET $26.68 each
APTIOM 600 MG TABLET $26.66 each
APTIOM 800 MG TABLET $26.75 each