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Cholinergic ToxicityAka: Cholinergic Overdose

Causes
1. Organophosphate Poisoning
2. Nerve Agent Exposure
Symptoms and Signs (Mnemonic: DUMBELLS or SLUDGe)
1. Diarrhea (and Diaphoresis) and abdominal cramping
2. Urination
3. Miosis (pinpoint pupils)
4. Bradycardia (muscarinic) or Tachycardia (nicotinic)
5. Emesis (Nausea and Vomiting)
6. Lacrimation
7. Lethargy
8. Salivation
Symptoms and signs: Other (not covered by mnemonic)
1. Anxiety or agitation
2. Seizures
3. Coma
4. Muscle fasciculations
5. Flaccid paralysis (including respiratory muscles)
Diagnostics
1. Electrocardiogram
Management
1. See Nerve Agent Exposure

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