Neurology Book

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AriceptAka: Donepezil

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  1. See Also
    1. Alzheimer's Disease
    2. Rivastigmine (Exelon)
    3. Galantamine (Reminyl)
  2. Mechanism
    1. Acetylcholinesterase inhibitor
  3. Indications
    1. Mild to Moderate Dementia (Folstein MMSE: 10-26)
  4. Adverse Effects
    1. Reduced adverse effects compared with Cognex
    2. No hepatotoxicity
  5. Dosing
    1. Start at 5 mg PO qhs
    2. Increase to 10 mg PO qhs after 4-6 weeks
  6. Efficacy
    1. As effective as Cognex
    2. Mini-Mental Status Exam changes
      1. Reduces decline by 3 points in 6 months
      2. Patient reverts to prior decline with Drug Withdrawal
    3. May be preferred over Galantamine
      1. Appears more effective than Galantamine
      2. Better tolerated than Galantamine
      3. Lanctot (2003) CMAJ 169:557
    4. Long-term use of Donepezil has minimal to no effect
      1. Does not prevent nursing home placement
      2. Minimally improves cognition
      3. Does not protect against longterm functional decline
      4. Courtney (2004) Lancet 363:2105
  7. Cost
    1. (2003) Red Book: $142 per month

Aricept (C0527315)

ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishAricept, Eisai brand of donepezil hydrochloride, Pfizer brand of donepezil hydrochloride
CreditsDerived from the NIH UMLS (Unified Medical Language System)


donepezil (C0527316)

Definition (NCI)The hydrochloride salt of a piperidine derivative with neurocognitive-enhancing activity. Donepezil reversibly inhibits acetylcholinesterase, thereby blocking the hydrolysis of the neurotransmitter acetylcholine and, consequently, increasing its activity. This agent may improve neurocognitive function in Alzheimer's disease, reduce sedation associated with opioid treatment of cancer pain, and improve neurocognitive function in patients who have received radiation therapy for primary brain tumors or brain metastases.
ConceptsOrganic Chemical (T109) , Pharmacologic Substance (T121)
EnglishDONEP, donepezil, DONEPEZIL PREPARATION
Spanishdonepecil, donepezil
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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