I. See Also

II. Interpretation

  1. Normal
    1. Newborn: <150 mg/dl
    2. Adult: 18 to 58 mg/dl
  2. CSF Protein is not related to Serum Protein levels
    1. Low Serum Protein does not cause low CSF Protein

III. Correction of Protein for CSF RBC

  1. Protein rises 1 mg/dl for every 1000 CSF RBCs
  2. Same tube must be used for protein and CSF RBC Count

IV. Increased CSF Protein

  1. Diabetes Mellitus
  2. Brain Tumor
    1. Meningioma
    2. Acoustic Neuroma
    3. Ependymoma
  3. Encapsulated brain abscess
  4. Spinal cord tumor
  5. Multiple Sclerosis
  6. Acute purulent Meningitis
  7. Granulomatous Meningitis
  8. Carcinomatous Meningitis
  9. Syphilis (protein may be normal if longstanding)
  10. Guillain-Barre Syndrome (Infectious polyneuritis)
    1. Protein normal during first few days
    2. Rises after first week
  11. Cushing's Disease
  12. Connective tissue disease
  13. Uremia
  14. Myxedema
  15. Cerebral Hemorrhage

V. Normal CSF Protein

  1. Brainstem Glioma
  2. Viral CNS Infections
  3. Multiple Sclerosis (protein may be mildly elevated)
  4. Ischemic Cerebrovascular Accident

VI. Decreased CSF Protein

  1. Recent Lumbar Puncture
  2. Chronic CSF leakage
  3. May be normal if age <2 years
  4. Acute water Intoxication

VII. References

  1. Kooiker in Roberts (1998) Procedures in ER, p. 1067-75
  2. Ravel (1995) Lab Medicine, Mosby, p. 294-9
  3. Tunkel in Mandell (2000) Infectious Disease, p. 974-8
  4. Seehusen (2003) Am Fam Physician 68:1103-8 [PubMed] (or open in [QxMD Read])

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Ontology: Cerebrospinal Fluid Proteins (C0007810)

Definition (MSH) Proteins in the cerebrospinal fluid, normally albumin and globulin present in the ratio of 8 to 1. Increases in protein levels are of diagnostic value in neurological diseases. (Brain and Bannister's Clinical Neurology, 7th ed, p221)
Concepts Amino Acid, Peptide, or Protein (T116) , Biologically Active Substance(T123)
MSH D002556
English Cerebrospinal Fluid Proteins, Fluid Proteins, Cerebrospinal, Proteins, Cerebrospinal Fluid, Cerebrospinal fluid proteins, CSF PROTEINS, PROTEINS CSF, Cerebrospinal Fluid Proteins [Chemical/Ingredient], cerebrospinal fluid proteins
Swedish Likvorproteiner
Czech mozkomíšní mok - proteiny
Finnish Aivo-selkäydinnesteen proteiinit
Russian SPINNOMOZGOVOI ZHIDKOSTI BELKI, СПИННОМОЗГОВОЙ ЖИДКОСТИ БЕЛКИ
Spanish Proteínas del Líquido Cefalorraquídeo, Proteinas del Liquido Cefalorraquideo
French Protéines du liquide cérébrospinal, Protéines du liquide céphalorachidien, Protéines du liquide céphalo-rachidien, Protéines du liquide cérébro-spinal
Croatian PROTEINI CEREBROSPINALNOG LIKVORA
Polish Białka płynu mózgowo-rdzeniowego
Japanese 脳脊髄液蛋白質, 髄液蛋白質
German Liquorproteine
Italian Proteine del liquido cerebrospinale
Portuguese Proteínas do Líquido Céfalorraquidiano