II. Background

  1. Represents 13-15% of CSF Protein

III. Indications

  1. Multiple Sclerosis diagnosis

IV. Differential Diagnosis: Elevated CSF Gamma Globulin

  1. Multiple Sclerosis
  2. Subacute Sclerosing Panencephalitis
  3. General paresis
  4. Herpes Encephalitis
  5. Myxedema
  6. Carcinomatous cerebellar degeneration
  7. Connective tissue disease

V. Preparations: Other Similar Tests

  1. IgG albumin ratio
  2. IgG synthesis rate
  3. Oligoclonal bands

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