II. Background

  1. Represents 13-15% of CSF Protein

III. Indications

  1. Multiple Sclerosis diagnosis

IV. Differential Diagnosis of elevated gamma globulin

  1. Multiple Sclerosis
  2. Subacute Sclerosing Panencephalitis
  3. General paresis
  4. Herpes Encephalitis
  5. Myxedema
  6. Carcinomatous cerebellar degeneration
  7. Connective tissue disease

V. Other Similar Tests

  1. IgG albumin ratio
  2. IgG synthesis rate
  3. Oligoclonal bands

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