II. Indications

  1. Ptosis evaluation in suspected Myasthenia Gravis

III. Contraindications

IV. Adverse Effects

  1. Increased Salivation
  2. Abdominal cramping
  3. Bradycardia
  4. Bronchospasm

V. Mechanism

  1. Edrophonium (Tensilon) is a rapid onset, short acting acetylcholinesterase inhibitor

VI. Preparation

  1. Consider telemetry monitoring
  2. Atropine 0.5 mg IV prn symptomatic Bradycardia

VII. Technique

  1. Edrophonium (10 mg/ml) 1 ml is drawn into a 1 cc syringe (tuberculin syringe)
  2. Inject edrophonium 2 mg (0.2 cc) IV every minute up to cummulative dose of 10 mg
  3. Stop when improvement in Ptosis is observed or 10 mg is reached (typically at 4-6 mg or 0.4 to 0.6 cc)

VIII. Interpretation

  1. Ptosis improvement with edrophonium is suggestive of Myasthenia Gravis

IX. Efficacy

  1. Test Sensitivity: 80-90%
  2. False positives
    1. Motor Neuron disorders
    2. Brainstem tumor
    3. Compressive cranial Neuropathy

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Ontology: Tensilon test (C1142121)

Concepts Diagnostic Procedure (T060)
SnomedCT 33981001
Italian Test all'edrofonio cloruro
English Tensilon test, Tensilon test (procedure), tensilon test, Edrophonium chloride test for myasthenia gravis, Tensilon test for myasthenia gravis, Edrophonium chloride test for myasthenia gravis (procedure), Edrophonium chloride test for myasthenia gravis (regime/therapy)
Japanese テンシロン試験, テンシロンシケン
Spanish prueba del cloruro de edrofonio para miastenia grave (régimen/tratamiento), prueba de Tensilon para la miastenia grave, prueba del cloruro de edrofonio para miastenia grave, Prueba con Tensilon, prueba del cloruro de edrofonio para miastenia grave (procedimiento)
Czech Test s podáváním přípravku Tensilon
Hungarian Tensilon vizsgálat
Portuguese Teste com Tensilon
Dutch tensilon test
French Epreuve au tensilon
German Tensilon-Test