II. Indications

  1. Multi-drug Tuberculosis Treatment regimen

III. Background

  1. Only 10% of drug penetrates Tb infected cells

IV. Dosing

  1. Adult: 1 gram (15 mg/kg) IM qd
  2. Pediatric: 20-40 mg/kg/day

V. Adverse Effects

  1. Cranial Nerve 8 and Vestibular toxicity
    1. Vertigo
    2. Decreased Hearing acuity or Deafness
  2. Renal damage

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