II. Indications

  1. Multi-drug Tuberculosis Treatment regimen

III. Background

  1. Only 10% of drug penetrates Tb infected cells

IV. Dosing

  1. Adult: 1 gram (15 mg/kg) IM qd
  2. Pediatric: 20-40 mg/kg/day

V. Adverse Effects

  1. Cranial Nerve 8 and Vestibular toxicity
    1. Vertigo
    2. Decreased hearing acuity or deafness
  2. Renal damage

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Ontology: Streptomycin (C0038425)

Definition (NCI) An aminoglycoside antibiotic derived from Streptomyces griseus with antibacterial activity. Streptomycin irreversibly binds to the 16S rRNA and S12 protein within the bacterial 30S ribosomal subunit. As a result, this agent interferes with the assembly of initiation complex between mRNA and the bacterial ribosome, thereby inhibiting the initiation of protein synthesis. In addition, streptomycin induces misreading of the mRNA template and causes translational frameshift, thereby results in premature termination. This eventually leads to bacterial cell death.
Definition (MSH) An antibiotic produced by the soil actinomycete Streptomyces griseus. It acts by inhibiting the initiation and elongation processes during protein synthesis.
Definition (CSP) first of the aminoglycoside antibiotics to be isolated; derived from Streptomyces griseus.
Concepts Antibiotic (T195) , Carbohydrate (T118)
MSH D013307
SnomedCT 387223008, 40877002
LNC LP16282-3, MTHU008482
English Streptomycin, streptomycin, D-Streptamine, O-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-O-5-deoxy-3-C-formyl-alpha-L-lyxofuranosyl-(1-4)-N,N'-bis(aminoiminomethyl)-, Streptomycin [Chemical/Ingredient], STREPTOMYCIN, antibacterial streptomycin, streptomycin (medication), Streptomycin (product), Streptomycin (substance)
Swedish Streptomycin
Czech streptomycin
Finnish Streptomysiini
Russian STREPTOMITSIN, СТРЕПТОМИЦИН
Japanese ストレプトマイシン
Polish Streptomycyna
Spanish estreptomicina (producto), estreptomicina (sustancia), estreptomicina, Estreptomicina
French Streptomycine
German Streptomycin
Italian Streptomicina
Portuguese Estreptomicina