II. Indication

  1. Cystic Fibrosis testing

III. Method

  1. Quantitative Pilocarpine Iontophoresis
    1. Stimulates local sweat production (parasympathetic)
    2. Collect sweat on gauze pads
    3. Analyze Sodium and chloride content
  2. Minimum sweat amount required: 50 mg (200 mg better)

IV. Normal

  1. Sweat contains <60 meq/Liter Chloride and Sodium

V. Abnormal Results

  1. CF Sweat contains > 70 meq/L Chloride and Sodium
  2. Error: >30 meq/L difference between chloride and Sodium

VI. Indications to repeat the test for confirmation

  1. Positive Test
  2. Suspected false negative

VII. False positive Tests

  1. Glucose 6 phosphate dehydrogenase deficiency (G6PD)
  2. Hypothyroidism
  3. Glycogen Storage Disease
  4. Untreated Adrenal Insufficiency
  5. Malnutrition

VIII. Reference

  1. Bakerman (1984) ABC's of Lab Data, ILD, Greenville, NC

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Ontology: Sweat test (C0430179)

Concepts Laboratory Procedure (T059)
SnomedCT 145410001, 145401009, 168181007, 168172001
English Sweat test NOS, sweat analysis, sweat testing, sweat test, sweat tests, Sweat test NOS (procedure), Sweat screening test, Sweat test, Sweat test (procedure)
Spanish Prueba del sudor, test del sudor, SAI (procedimiento), Sweat test NOS, test del sudor, SAI, prueba del sudor (procedimiento), prueba del sudor
Dutch zweettest
German Schweisstest
Japanese カンシケン, 汗試験, アセシケン
Czech Vyšetření potu
Portuguese Teste do suor
Italian Test del sudore
French Test de la sueur
Hungarian Verejték vizsgálat