I. Preparations

  1. Bacitracin
  2. Mupirocin (Bactroban) 2% ointment
    1. Impetigo: Applied three times daily to affected area for 7-10 days
    2. May be used in age 2 months and older
    3. Available as 22 g tube (ointment is less expensive than creams)
    4. Emerging Streptococcal resistance in 2014
  3. Retapamulin (Altabax) 1% ointment
    1. Impetigo: Apply twice daily to affected area for 5 days
    2. May be used in age 9 months and older
    3. Treatment area must be <100 cm2 (or <2% total BSA in children)
  4. Fusidic Acid 2% cream (Not available in United States)
    1. Impetigo: Apply three times daily to affected area for 10-12 days
    2. Koning (2002) BMJ 324:203-6

Images: Related links to external sites (from Google)

Cost: Medications

Bacitracin-Polymyxin B (on 2/9/2012 at DrugStore.com)
Bacitracin-Polymyxin B 500-10000unit/gm Ointment 3.5gm Tube #1 for $31.99 ($31.99/unit)
Bactroban (on 2/9/2012 at DrugStore.com)
Bactroban 2% Ointment 22gm Tube #1 for $79.99 ($79.99/unit)
Bactroban 2% Cream 15gm Tube #1 for $64.99 ($64.99/unit)
Bactroban 2% Cream 30gm Tube #1 for $96.99 ($96.99/unit)
Bactroban Nasal (on 2/9/2012 at DrugStore.com)
Bactroban Nasal 2% Ointment 1gm Tube #1 for $19.99 ($19.99/unit)
Mupirocin (on 2/9/2012 at DrugStore.com)
Mupirocin 2% Ointment 22gm Tube #1 for $37.99 ($37.99/unit)
Altabax (on 2/9/2012 at DrugStore.com)
Altabax 1% Ointment 5gm Tube #1 for $49.33 ($49.33/unit)
Altabax 1% Ointment 10gm Tube #1 for $74.56 ($74.56/unit)
Altabax 1% Ointment 15gm Tube #1 for $99.99 ($99.99/unit)

Ontology: Bacitracin (C0004599)

Definition (MSH) A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140)
Definition (NCI) A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth.
Concepts Amino Acid, Peptide, or Protein (T116) , Antibiotic(T195)
MSH D001414
SnomedCT 255965000, 5220000, 370330005
English Bacitracin, NOS, bacitracin, bacitracin (medication), BACITRACIN, Bacitracin [Chemical/Ingredient], bacitracins, Bacitracin (substance), Bacitracin product (product), Bacitracin product, BAC, Bacitracin, Bacitracin [dup] (substance)
Swedish Bacitracin
Czech bacitracin
Spanish Bacitracin, Bacitracin [dup] (substance), bacitracina (producto), producto con bacitracina (producto), producto con bacitracina, bacitracina (sustancia), bacitracina, Bacitracina
Finnish Basitrasiini
Russian BATSITRATSIN, БАЦИТРАЦИН
Polish Bacytracyna
Japanese バシトラシン, アイフィビス
French Bacitracine
German Bacitracin
Italian Bacitracina
Portuguese Bacitracina

Ontology: Mupirocin (C0085259)

Definition (MSH) A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Definition (NCI) A natural crotonic acid derivative extracted from Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by specific reversible binding to bacterial isoleucyl tRNA synthase. With excellent activity against gram-positive staphylococci and streptococci, it is primarily used for treatment of primary and secondary skin disorders, nasal infections, and wound healing. (NCI04)
Concepts Lipid (T119) , Antibiotic(T195)
MSH D016712
SnomedCT 387397004, 71453003
English Acid, Pseudomonic, Mupirocin, Pseudomonic Acid, Pseudomonic Acid A, Nonanoic acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2H-pyran-2-yl)-2-butenyl)oxy)-, (2S-(2alpha(E),3beta,4beta,5alpha(2R*,3R*(1R*,2R*))))-, mupirocin, mupirocin (medication), MUPIROCIN, Mupirocin [Chemical/Ingredient], pseudomonic acid a, Pseudomonic acid, Pseudomonic acid A, Mupirocin (product), Mupirocin (substance)
Spanish Ácido Pseudomónico, Acido Pseudomonico, mupirocina (producto), mupirocina (sustancia), mupirocina, ácido pseudomónico A, ácido pseudomónico, ácido seudomónico, Acido Seudomonico, Mupirocina, Ácido Seudomónico
Swedish Mupirocin
Czech mupirocin
Finnish Mupirosiini
Russian MUPIROTSIN, PSEVDOMONOVAIA KISLOTA, МУПИРОЦИН, ПСЕВДОМОНОВАЯ КИСЛОТА
Italian Acido pseudomonico, Acido pseudomonico A, Mupirocina
Polish Mupirocyna, Kwas pseudomonowy
Japanese プソイドモニックアシド, ムピロシン
French Acide pseudomonique, Mupirocine
German Mupirocin, Pseudomonassäure
Portuguese Ácido Pseudomônico, Mupirocina

Ontology: Bactroban (C0733863)

Concepts Lipid (T119) , Antibiotic(T195)
MSH D016712
English bactroban, Bactroban