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Topical AntibioticsAka: Bacitracin, Bactroban, Mupirocin
- Preparations
- Bacitracin
- Mupirocin (Bactroban)
- Retapamulin (Altabax)
Bacitracin (C0004599) | |
|---|---|
| Definition (MSH) | A complex of cyclic peptide antibiotics produced by the Tracy-I strain of Bacillus subtilis. The commercial preparation is a mixture of at least nine bacitracins with bacitracin A as the major constituent. It is used topically to treat open infections such as infected eczema and infected dermal ulcers. (From Goodman and Gilman, The Pharmacological Basis of Therapeutics, 8th ed, p1140) |
| Definition (NCI) | A complex of cyclic polypeptide antibiotics, mainly bacitracin A, produced by spore-forming organisms belonging to the licheniformin group of the Bacillus subtilis with antibacterial activity. Bacitracin binds to C55-isoprenyl pyrophosphate, a biphosphate lipid transport molecule that carries the building blocks of the peptidoglycan bacterial cell wall. The binding interferes with the enzymatic dephosphorylation of the C55-isoprenyl pyrophosphate and prevents peptidoglycan synthesis, thereby inhibiting bacterial cell growth. |
| Concepts | Amino Acid, Peptide, or Protein (T116) , Antibiotic (T195) |
| MSH | D001414 |
| English | BAC, Bacitracin, BACITRACIN PREPARATION, Bacitracin product |
| Spanish | bacitracina, producto con bacitracina |
| Parent Concepts | Antibiotics (C0003232), Cyclic Peptides (C0030957), [AM900] ANTI-INFECTIVES, OTHER (C0973485), [DE101] ANTIBACTERIAL, TOPICAL (C0973519), [OP201] ANTIBACTERIALS, TOPICAL OPHTHALMIC (C0973596), Anti-Bacterial Agents (C0279516), Drug allergen (C1320237), Duplicate concept (C1274013), Miscellaneous Antibacterials (C1579351), Ophthalmic Antibacterials (C1579376) |
| Sources | AOD, CSP, LCH, LNC, MSH, MTH, MTHSPL, NCI, NDFRT, PDQ, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Mupirocin (C0085259) | |
|---|---|
| Definition (MSH) | A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing. |
| Definition (NCI) | A natural crotonic acid derivative extracted from Pseudomonas fluorescens. Mupirocin inhibits bacterial protein synthesis by specific reversible binding to bacterial isoleucyl tRNA synthase. With excellent activity against gram-positive staphylococci and streptococci, it is primarily used for treatment of primary and secondary skin disorders, nasal infections, and wound healing. (NCI04) |
| Concepts | Lipid (T119) , Antibiotic (T195) |
| MSH | D016712 |
| English | Mupirocin, MUPIROCIN PREPARATION, Pseudomonic Acid, Pseudomonic Acid A |
| Spanish | acido pseudomonico, acido pseudomonico A, acido seudomonico, mupirocina |
| Parent Concepts | Epoxy Compounds (C0014630), Fatty Acids (C0015684), Pyrans (C0034234), Anti-Infective Agents, Local (C0003205), [DE101] ANTIBACTERIAL, TOPICAL (C0973519), Anti-Bacterial Agents (C0279516), Skin anti-infective (C0304580), Drug allergen (C1320237), Dermatological Antibacterials (C1579273) |
| Sources | LNC, MSH, MTHSPL, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, USPMG, VANDF Derived from the NIH UMLS (Unified Medical Language System) |
Bactroban (C0733863) | |
|---|---|
| Concepts | Lipid (T119) , Antibiotic (T195) |
| MSH | D016712 |
| English | Bactroban |
| Sources | MSH, NCI, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
