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Pyrimethamine sulfadoxineAka: Fansidar, Daraprim
- Indications: Malaria Prophylaxis and Treatment
- Areas with Chloroquine resistance
- Not recommended for routine prophylaxis
- Treatment in breakthrough Chloroquine Resistance
- Preparations
- Tablet: 25/500
- Directions
- Taking with food decreases gastric irritation
- Dosing: Prophylaxis
- Child
- Age 2-11 months: 1/8 tablet PO each week
- Age 1-3 years: 1/4 tablet PO each week
- Age 4-8 years: 1/2 tablet PO each week
- Age 9-14 years: 3/4 tablet PO each week
- Adolescent (over age 14 years): 1 tablet PO each week
- Adult: 25/500 mg tablet PO each week
- Dosing: Treatment
- Adult: 75/1500 mg for 1 dose
- Child: Double dose of prophylactic dose
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| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Daraprim, Glaxo Wellcome Brand of Pyrimethamine, GlaxoSmithKline Brand of Pyrimethamine, Wellcome Brand of Pyrimethamine |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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sulfadoxine-pyrimethamine (C0700599)
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| Definition (NCI) | A combination product containing pyrimethamine and sulfadoxine. Pyrimethamine is a competitive inhibitor of dihydrofolate reductase (DHFR). DHFR is a key enzyme in the redox cycle for production of tetrahydrofolate, a cofactor that is required for the synthesis of DNA and proteins. Sulfadoxine competitively antagonizes paraaminobenzoic acid (PABA), resulting in disruption of folic acid synthesis and ultimately DNA synthesis. Sulfadoxine acts synergistically with pyrimethamine. (NCI04) |
| Concepts | Organic Chemical (T109)
, Pharmacologic Substance (T121)
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| English | Pyrimethamine + sulfadoxine, Pyrimethamine + sulphadoxine, Pyrimethamine Sulfadoxine, Pyrimethamine with sulfadoxine, Pyrimethamine with sulphadoxine, PYRIMETHAMINE/SULFADOXINE, Sulfadoxine and Pyrimethamine |
| Spanish | pirimetamina + sulfadoxina, pirimetamina con sulfadoxina |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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