II. Indications: Malaria Prophylaxis and Treatment

  1. Areas with Chloroquine resistance
  2. Not recommended for routine prophylaxis
  3. Treatment in breakthrough Chloroquine Resistance

III. Medications

  1. Tablet: Pyrimethamine 25 mg and sulfadoxine 500 mg
    1. Taking with food decreases gastric irritation

IV. Dosing: Prophylaxis

  1. Adult (and age >=14 years)
    1. Pyrimethamine Sulfadoxine 25/500 mg tablet orally each week
  2. Child (age <14 years)
    1. Age 2-11 months: 1/8 tablet orally each week
    2. Age 1-3 years: 1/4 tablet orally each week
    3. Age 4-8 years: 1/2 tablet orally each week
    4. Age 9-14 years: 3/4 tablet orally each week

V. Dosing: Treatment

  1. Adult: 75/1500 mg for one dose
  2. Child: Double dose of prophylactic dose

VI. Adverse Effects

VII. Resources

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