II. Indications

  1. Methicillin-Resistant Staphylococcus aureus (MRSA)
  2. Complicated Skin Infections
  3. Do not use for Pneumonia
    1. Poorly penetrates lung
    2. Inactivated by surfactant

III. Mechanism

  1. Cyclic Lipopeptide
  2. Depolarizes Bacterial cell membranes

IV. Preparations

  1. Intravenous daily dosing

V. Dosing

  1. Adults: 4 mg/kg in NS over 30 minutes once daily

VI. Adverse Effects

  1. Muscle toxicity (avoid concurrent Statin use)

VII. Monitoring

  1. Obtain serum CPK level weekly while on Daptomycin

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Ontology: Daptomycin (C0057144)

Definition (MSH) A cyclic lipopeptide antibiotic that inhibits GRAM-POSITIVE BACTERIA.
Definition (NCI) A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum antibiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria.
Definition (NCI_NCI-GLOSS) A drug used to treat certain bacterial skin and bloodstream infections in adults. Cubicin is also being studied in the treatment of fever and neutropenia (an abnormal decrease in the number of neutrophils, a type of white blood cell) in patients with cancer. It is a type of antibiotic.
Definition (PDQ) A semi-synthetic cyclic lipopeptide antibiotic isolated form the bacterium Streptomyces roseosporus with broad-spectrum anitbiotic activity against Gram-positive bacteria. Daptomycin has a distinct mechanism of action, in which it binds to bacterial membrane and causes rapid depolarization of the cell membrane due to calcium-dependant potassium efflux; the loss of membrane potential leads to inhibition of DNA, RNA and protein synthesis, resulting in bacterial cell death. This agent does not penetrate the outer membrane of gram-negative bacteria. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=469015&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=469015&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C47470" NCI Thesaurus)
Concepts Antibiotic (T195) , Amino Acid, Peptide, or Protein (T116)
MSH D017576
SnomedCT 406438001, 406439009
LNC LP33354-9, MTHU016673
English Daptomycin, Deptomycin, N-Decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine epsilon1-lactone, N-decanoyl-L-tryptophyl-L-asparaginyl-L-aspartyl-L-threonylglycyl-L-ornithyl-L-aspartyl-D-alanyl-L-aspartylglycyl-D-seryl-threo-3-methyl-L-glutamyl-3-anthraniloyl-L-alanine-epsilon1-lactone, daptomycin (medication), Daptomycin [Chemical/Ingredient], DAPTOmycin, daptomycin, Daptomycin (product), Daptomycin (substance), DAPTOMYCIN
Swedish Daptomycin
Czech daptomycin
Finnish Daptomysiini
Russian DAPTOMITSIN, ДАПТОМИЦИН
Japanese ダプトマイシン
Polish Daptomycyna
Spanish daptomicina (producto), daptomicina (sustancia), daptomicina, Daptomicina
French Daptomycine
German Daptomycin
Italian Daptomicina
Portuguese Daptomicina

Ontology: Cyclic lipopeptide antibiotic (C1320334)

Concepts Antibiotic (T195) , Organic Chemical (T109)
SnomedCT 406437006, 406440006
Spanish lipopéptidos cíclicos, lipopéptidos cíclicos (producto), lipopéptidos cíclicos (sustancia), antibiótico lipopeptídico cíclico, antibiótico lipopeptídico cíclico (sustancia), antibiótico lipopeptídico cíclico (producto), antibióticos lipopéptidos cíclicos (producto), ántibióticos lipopéptidos cíclicos (sustancia), antibióticos lipopéptidos cíclicos, ántibióticos lipopéptidos cíclicos
English Cyclic lipopeptides, Cyclic lipopeptide antibiotic (product), Cyclic lipopeptide antibiotic (substance), Cyclic lipopeptide antibiotic, Cyclic lipopeptides (product), Cyclic lipopeptides (substance)

Ontology: Cubicin (C1330170)

Concepts Amino Acid, Peptide, or Protein (T116) , Antibiotic (T195)
MSH D017576
English Cubist Brand of Injectable Daptomycin, Cubicin