II. Method

  1. Latex agglutination test
  2. Identifies serum Antibody to streptolysin O
    1. Group A Streptococcus Oxygen labile hemolysin

III. Mechanism

  1. Sensitive for acute streptococcal infection
    1. Early Penicillin prevents ASO rise
  2. Increases within one week of infection
  3. Peaks 2-4 weeks after infection

IV. Normal

  1. Age 5-12 years: <333 I.U.
  2. Young Adults: <200 I.U.

V. Increased

  1. Streptococcus respiratory infection
  2. Acute Rheumatic Fever (80%)
  3. Acute Glomerulonephritis (95%)
    1. Membranoproliferative Glomerulonephritis (20%)
    2. Acute Poststreptococcal Glomerulonephritis (70%)

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