Infectious Disease Book

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Rabies Vaccine

Aka: Rabies Vaccine, Rabies Prophylaxis
  1. See Also
    1. Rabies
    2. Dog Bite
  2. Indications
    1. Post-Exposure Prophylaxis
    2. Pre-Exposure Prophylaxis
      1. Veterinarians
      2. Animal control and wildlife professionals
      3. Lab workers
      4. Adventure travelers to Rabies endemic areas
      5. Archaeology work
  3. Preparations
    1. General
      1. All preparations in U.S. produced in cell culture
      2. Safer than infected animal brain preparations
    2. HDCV (Imovax)
      1. Human Diploid Cells
      2. Risk of Serum Sickness risk on booster doses: 6%
    3. RVA (Rabies Vaccine Absorbed)
      1. Fetal rhesus diploid lung cells
    4. PCEC (RabAvert)
      1. Developed in chick Embryo
      2. New preparation with fewer side effects
      3. Contraindicated in severe egg allergy
  4. Adverse Effects
    1. Mild erythema, swelling, and local pain
    2. Serum Sickness (Type III) Hypersensitivity Reaction
      1. Seen with HDCV on booster dose
  5. Protocol: Post-Exposure Prophylaxis
    1. Wash wound with soap and water
    2. Human Rabies immune globulin 20 IU/kg
      1. Inject into and around all wound sites
      2. Neutralize Rabies virus before it enters nerve
    3. Rabies Vaccine (HDCV, RVA, PCEC)
      1. Administer 1 ml Vaccine IM in Deltoid
      2. Days 0, 3, 7, 14, 28
      3. Five Dose course costs $700 - $800
    4. Prior cell-culture vaccine OR Antibody response
      1. No immune globulin needed
      2. Rabies Vaccine on Days 0, 3
  6. Protocol: Pre-Exposure Prophylaxis
    1. Rabies Vaccine 1 ml IM deltoid days 0, 7, and 21-28
  7. Precautions
    1. Safe in HIV and Pregnancy
  8. References
    1. Wilde (2003) Clin Infect Dis 37:96-100

Rabies Vaccines (C0034496)

Definition (MSH) Vaccines or candidate vaccines used to prevent and treat RABIES. The inactivated virus vaccine is used for preexposure immunization to persons at high risk of exposure, and in conjunction with rabies immunoglobulin, for postexposure prophylaxis.
Definition (CSP) vaccines or candidate vaccines used to prevent and/or treat rabies.
Definition (HL7V3.0) rabies vaccine, NOS
Concepts Organic Chemical (T109) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
MSH D011819
SnomedCT 333606008, 396437008
HL7 90
English Rabies vaccines, Rabies Human Diploid Cell Vaccine, Rabies Vaccine, Vaccine, Rabies, rabies vaccine, Rabies Vaccine,Human Diploid, rabies vaccine, human diploid cell, Rabies Vaccines [Chemical/Ingredient], rabies vaccines, vaccines rabies, Vaccines, Rabies, Rabies vaccine, Rabies vaccine (product), Rabies vaccine (substance), rabies, NOS, Rabies Vaccines, RABIES VACCINE
Spanish Vacunas contra la Rabia, Vacunas Antirrabicas, Vacunas Antirrábicas, vacuna antirrábica (producto), vacuna antirrábica (sustancia), vacuna antirrábica
Swedish Rabiesvacciner
Czech vzteklina - vakcíny, rabies - vakcíny
Finnish Vesikauhurokotteet
Russian VAKTSINY PROTIV BESHENSTVA, ВАКЦИНЫ ПРОТИВ БЕШЕНСТВА
Japanese 狂犬病ワクチン, ワクチン-狂犬病
Italian Vaccino rabico, Vaccino rabico su cellule umane diploidi, Vaccini rabici
Croatian BJESNOĆA, CJEPIVA
Polish Szczepionki przeciw wściekliźnie
French Vaccins antirabiques
German Impfstoffe, Rabies-, Impfstoffe, Tollwut-, Rabiesvakzinen, Tollwutimpfstoffe, Tollwutvakzinen, Vakzinen, Rabies-, Vakzinen, Tollwut-
Portuguese Vacinas Anti-Rábicas, Vacinas contra Raiva
Sources
Derived from the NIH UMLS (Unified Medical Language System)


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