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Pneumococcal Conjugate VaccineAka: Heptavalent Pneumococcal Conjugate Vaccine, Prevnar
- Indications: Pediatric Vaccine
- Primary Immunization series for young children
- Pharmacology
- Seven valent vaccine covers serotypes affecting children
- Serotypes: 4, 6B, 9V, 14, 18C, 19F, 23F
- These serotypes are responsible for >80% of Meningitis and bacteremia in age <6 years
- Components
- Pneumococcal polysaccharide conjugated to non-toxic Diphtheria toxin
- Differs from the adult vaccine (Pnu-Imune 23)
- Prevnar is more immunogenic
- Prevnar does not contain Thimerosal
- Seven valent vaccine covers serotypes affecting children
- Importance of vaccine
- Infections caused by Streptococcus Pneumoniae (age <6)
- Community acquired Pneumonia (leading cause)
- Otitis Media (leading cause)
- Bacterial Meningitis (leading cause)
- Streptococcus bacteremia
- Antibiotic Resistance is growing
- Penicillin Resistant Pneumococcus now 24% of isolates
- Infections caused by Streptococcus Pneumoniae (age <6)
- Efficacy: Highly effective
- Prevents 94-97% invasive disease by immunized serotypes
- Decreases Acute Otitis Media episodes in infants
- Adverse Effects
- No serious adverse effects
- Fever to 38 F
- Local inflammation at injection site
- Dosing: Regular Schedule started in infancy
- Four doses: 2, 4, 6 and 12 to 15 months
- Dosing: Catch up dosing based on age at first dose
- Age 2 to 6 months
- Primary Series: 3 doses, two months apart
- Booster: 12 to 15 months
- Age 7 to 11 months
- Primary Series: 2 doses, two months apart
- Booster: 12 to 15 months
- Age 12 to 23 months
- Primary Series: 2 doses, two months apart
- Age 24 to 59 months in healthy child
- Primary Series: one dose
- Age 24 to 59 months in child with chronic illness
- Indicated conditions
- Sickle Cell Anemia
- Asplenic patient
- HIV Infection
- Other chronic illness
- Immunocompromising condition
- Primary Series: two doses, two months apart
- Indicated conditions
- Age 5 years and older
- Vaccination not recommended
- Age 2 to 6 months
- References
heptavalent pneumococcal conjugate vaccine (C0389545) | |
|---|---|
| Concepts | Amino Acid, Peptide, or Protein (T116) , Immunologic Factor (T129) |
| MSH | C099433 |
| English | 7-valent PncOMPC vaccine, heptavalent pneumococcal conjugate vaccine, PNCRM7, seven-valent pneumococcal PS-meningococcal OMPC conjugate vaccine |
| Sources | MSH, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
Prevenar (C0876134) | |
|---|---|
| Concepts | Amino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129) |
| MSH | C099433 |
| English | Prevenar, Prevnar |
| Sources | MSH, NCI, RXNORM Derived from the NIH UMLS (Unified Medical Language System) |
Pneumococcal Conjugate Vaccine (C1579319) | |
|---|---|
| Concepts | Organic Chemical (T109) , Pharmacologic Substance (T121) , Immunologic Factor (T129) |
| English | Pneumococcal Conjugate Vaccine |
| Parent Concepts | Vaccines (C0042210) |
| Sources | USPMG Derived from the NIH UMLS (Unified Medical Language System) |
