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Pneumococcal Conjugate VaccineAka: Prevnar
- Indications: Pediatric Vaccine
- Primary Immunization series for young children
- Pharmacology
- Seven valent vaccine covers serotypes affecting kids
- Serotypes: 4, 6B, 9V, 14, 18C, 19F, 23F
- Differs from the adult vaccine (Pnu-Imune 23)
- Prevnar is more immunogenic
- Prevnar does not contain Thimerosal
- Importance of vaccine
- Infections caused by Streptococcus Pneumoniae (age <6)
- Community acquired Pneumonia (leading cause)
- Otitis Media (leading cause)
- Bacterial Meningitis (leading cause)
- Streptococcus bacteremia
- Antibiotic Resistance is growing
- Penicillin Resistant Pneumococcus now 24% of isolates
- Efficacy: Highly effective
- Prevents 94-97% invasive disease by immunized serotypes
- Decreases Acute Otitis Media episodes in infants
- Adverse Effects
- No serious adverse effects
- Fever to 38 F
- Local inflammation at injection site
- Dosing: Regular Schedule started in infancy
- Four doses: 2, 4, 6 and 12 to 15 months
- Dosing: Catch up dosing based on age at first dose
- Age 2 to 6 months
- Primary Series: 3 doses, two months apart
- Booster: 12 to 15 months
- Age 7 to 11 months
- Primary Series: 2 doses, two months apart
- Booster: 12 to 15 months
- Age 12 to 23 months
- Primary Series: 2 doses, two months apart
- Age 24 to 59 months in healthy child
- Primary Series: one dose
- Age 24 to 59 months in child with chronic illness
- Indicated conditions
- Sickle Cell Anemia
- Asplenic patient
- HIV Infection
- Other chronic illness
- Immunocompromising condition
- Primary Series: two doses, two months apart
- References
- Black (2000) Pediatr Infect Dis J 19:187
- Eskola (2001) N Engl J Med 344:403
- Rennels (1998) Pediatrics 101(4 pt 1):604
- Shinefield (1999) Pediatr Infect Dis J 18:757
- Zimmerman (2001) Am Fam Physician 63(10):1991
- (2000) MMWR Morb Mortal Wkly Rep 49(RR-9):1
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| Concepts | Amino Acid, Peptide, or Protein (T116)
, Pharmacologic Substance (T121)
, Immunologic Factor (T129)
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| English | Prevenar, Prevnar |
| Credits | Derived from the NIH UMLS (Unified Medical Language System)
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