Infectious Disease Book

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Human Papilloma Virus VaccineAka: Quadrivalent Human Papillomavirus Vaccine, HPV Vaccine, Gardasil

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  1. Indications
    1. Prevention of Cervical Dysplasia
    2. Females routinely at age 12 and catch-up <26 years
  2. Mechanism
    1. Mixture of primary capsid proteins of 4 HPV types
    2. Two low risk HPV types (but cause most Genital Warts)
      1. HPV 6
      2. HPV 11
    3. Two high risk HPV types
      1. HPV 16
      2. HPV 18
  3. Contraindications
    1. Pregnancy
  4. Adverse Effects
    1. Local pain at injection site: 80%
    2. Local redness or swelling: 25%
    3. Fever
      1. Low grade in 10%
      2. Over 102 degrees in 1.4%
  5. Dosings
    1. Intramuscular injection
    2. Schedule: 0, 2, and 6 months
  6. Cost
    1. Three doses: $440 (covered by most U.S. insurance plans)
  7. References
    1. Goeser (2007) Am Fam Physician 76:573-4

Human Papilloma Virus Vaccine (C1512511)

Definition (NCI)A recombinant vaccine of different types of HPV proteins which are well-conserved within types with a significant inter-type variation.
Definition (HL7V3.0)human papilloma virus vaccine
ConceptsAmino Acid, Peptide, or Protein (T116) , Pharmacologic Substance (T121) , Immunologic Factor (T129)
EnglishHPV, HPV Vaccine, HPV Vaccines, Human Papilloma Virus Vaccine, Human Papilloma Virus Vaccines, Human papillomavirus vaccine, Human Papillomavirus Vaccines
CreditsDerived from the NIH UMLS (Unified Medical Language System)


Gardasil (C1721787)

ConceptsPharmacologic Substance (T121) , Immunologic Factor (T129)
EnglishGardasil, Merck brand of HPV quadrivalent vaccine
CreditsDerived from the NIH UMLS (Unified Medical Language System)



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