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Human Papilloma Virus Vaccine
Aka: Human Papilloma Virus Vaccine, Quadrivalent Human Papillomavirus Vaccine, HPV Vaccine, Gardasil
- Indications
- General indications
- Prevention of Cervical Dysplasia
- Prevention of anal cancer (receptive anal intercourse)
- Girls and women: Part of Primary Series
- Females routinely at age 12 and catch-up age <26 years
- Boys and men
- Not part of primary seeries for males
- FDA approved for for males aged 9 to 26
- Mechanism
- Mixture of primary capsid proteins of 4 HPV types (Quadrivalent)
- Two low risk HPV types (but cause 90% of Genital Warts)
- HPV 6
- HPV 11
- Two high risk HPV types (cause 70% of Cervical Cancers)
- HPV 16
- HPV 18
- Contraindications
- Pregnancy
- Anaphylaxis to yeast
- Adverse Effects
- Local pain at injection site: 80%
- Local redness or swelling: 25%
- Fever
- Low grade in 10%
- Over 102 degrees in 1.4%
- Efficacy
- Highest efficacy when administered prior to onset of sexual activity
- Dosings
- Intramuscular Injection
- Schedule: 0, 2, and 6 months
- Cost
- Three doses: $440 (covered by most U.S. insurance plans)
- References
- Goeser (2007) Am Fam Physician 76:573-4
- Villa (2005) Lancet Oncol 6:271-8