Infectious Disease Book

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BCG vaccineAka: Bacille Calmette-Guerin Vaccine

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  1. See Also
    1. Tuberculosis
    2. Tuberculosis Screening in Chuldren
  2. Definition
    1. Tuberculosis vaccine commonly used outside of U.S.
  3. Indications
    1. General
      1. Routinely given to children in Tb endemic regions
      2. Not typically used in the United States
      3. Use directed by local Tuberculosis control program
    2. May be indicated in young children at high risk for Tb
      1. Consider for frequent exposure to active Tuberculosis
      2. See efficacy below regarding use in young children
  4. Background
    1. Live attenuated vaccine with Mycobacterium bovis
  5. Adverse effects
    1. Disseminated disease in immunodeficient patients
      1. Deeks (2005) Pediatr Infect Dis 24:538
  6. Efficacy
    1. BCG may reduce severe disseminated Tb in young children
    2. BCG vaccine protects against infection in children
      1. Soysal (2005) Lancet 366:1443

BCG Vaccine (C0004886)

Definition (MSH)An active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections. It is used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
Definition (CSP)active immunizing agent and a viable avirulent attenuated strain of Mycobacterium tuberculosis, var. bovis, which confers immunity to mycobacterial infections; used also in immunotherapy of neoplasms due to its stimulation of antibodies and non-specific immunity.
Definition (NCI)BCG. A type of bacteria used in cancer treatment to stimulate the immune system. It is also used to vaccinate against tuberculosis.
Definition (NCI)An attenuated strain of Mycobacterium bovis with non-specific immunoadjuvant and immunotherapeutic properties. Although the mechanism of its anti-tumor activity is unclear, immunization with BCG (Bacillus Calmette-Guerin) likely activates a Th1 cytokine response that includes induction of interferon. Vaccination with BCG may be immunoprotective against infection with Mycobacterium tuberculosis. (NCI04)
Definition (HL7V3.0)Bacillus Calmette-Guerin vaccine
ConceptsPharmacologic Substance (T121) , Immunologic Factor (T129)
MSHD001500
EnglishAttenuated Bacillus Calmette Guerin, Bacille Calmette-Guerin Live, Bacillius Calmette-Guerin Vaccine, Bacillus Calmette Guerin, Bacillus Calmette Guerin Vaccine, Bacillus Calmette-Guerin, Bacillus Calmette-Guerin vaccine, BACILLUS CALMETTE-GUERIN VACCINE PREPARATION, BCG, BCG Vaccine, Calmette Guerin Bacillus Vaccine, Calmette Vaccine, Calmette's Vaccine, Calmettes Vaccine, Live Intravesical BCG
Spanishbacilo de Calmette Guerin atenuado, bacilo de Calmette-Guerin atenuado, BCG atenuado, vacuna BCG, vacuna del Bacilo Calmette-Guerin, vacuna del bacilo de Calmette-Guerin
Parent ConceptsTuberculosis Vaccines (C0041305), neoplasm/cancer vaccine (C0597031), Vaccines administered (code = CVX)(parenteral, unless oral is noted) (C1547693), VaccineType (C1554000), Vaccine Adjuvant (C1519886), Attenuated Bacteria (C1879753), Vaccines (C0042210), Other antineoplastic drugs (C0356919), Unclassified Ingredients (C1372954), Antineoplastic Agents (C0003392), Bacterial Vaccines (C0004632), Erroneous concept (C1274015)
SourcesCSP, HL7V2.5, HL7V3.0, MSH, MTH, NCI, NDFRT, RXNORM, SCTSPA, SNOMEDCT, VANDF
Derived from the NIH UMLS (Unified Medical Language System)



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